Trace-element levels in tissues of rats and dogs treated with cis-diammine/1,1-cyclobutanedicarboxylato/platinum/II/ /Carboplatin/

P. S. Tjioe, Jacques J. Kroon, P. Lelieveld, W. J.F. van der Vijgh

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

Platinum and eleven other trace elements were determined by radiochemical neutron activation analysis in tissues of healthy rats and dogs treated with the anti-cancer drug carboplatin. In rats the levels of the trace elements were not much influenced; in the kidney only the Co and the Sb levels were decreased and in the liver only the Mo level was increased. A parallel tendency in the Co and Mo metabolism was seen in dogs. Carboplatin treatment tends to reduce the Cd, Co and Fe levels in metabolic active organs, kidney, liver, spleen and/or pancreas of the dog.

Original languageEnglish
Pages (from-to)103-113
Number of pages11
JournalJournal of Radioanalytical and Nuclear Chemistry Letters
Volume104
Issue number2
DOIs
Publication statusPublished - 1 Mar 1986
Externally publishedYes

Fingerprint

Dive into the research topics of 'Trace-element levels in tissues of rats and dogs treated with cis-diammine/1,1-cyclobutanedicarboxylato/platinum/II/ /Carboplatin/'. Together they form a unique fingerprint.

Cite this