Platinum and eleven other trace elements were determined by radiochemical neutron activation analysis in tissues of healthy rats and dogs treated with the anti-cancer drug carboplatin. In rats the levels of the trace elements were not much influenced; in the kidney only the Co and the Sb levels were decreased and in the liver only the Mo level was increased. A parallel tendency in the Co and Mo metabolism was seen in dogs. Carboplatin treatment tends to reduce the Cd, Co and Fe levels in metabolic active organs, kidney, liver, spleen and/or pancreas of the dog.
|Number of pages||11|
|Journal||Journal of Radioanalytical and Nuclear Chemistry Letters|
|Publication status||Published - 1 Mar 1986|