Trace-element levels in tissues of rats and dogs treated with cis-diammine/1,1-cyclobutanedicarboxylato/platinum/II/ /Carboplatin/

P. S. Tjioe; Jacques J. Kroon; P. Lelieveld; W. J.F. van der Vijgh

doi:10.1007/BF02166925

Trace-element levels in tissues of rats and dogs treated with cis-diammine/1,1-cyclobutanedicarboxylato/platinum/II/ /Carboplatin/

P. S. Tjioe, Jacques J. Kroon, P. Lelieveld, W. J.F. van der Vijgh

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Platinum and eleven other trace elements were determined by radiochemical neutron activation analysis in tissues of healthy rats and dogs treated with the anti-cancer drug carboplatin. In rats the levels of the trace elements were not much influenced; in the kidney only the Co and the Sb levels were decreased and in the liver only the Mo level was increased. A parallel tendency in the Co and Mo metabolism was seen in dogs. Carboplatin treatment tends to reduce the Cd, Co and Fe levels in metabolic active organs, kidney, liver, spleen and/or pancreas of the dog.

Original language	English
Pages (from-to)	103-113
Number of pages	11
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	104
Issue number	2
DOIs	https://doi.org/10.1007/BF02166925
Publication status	Published - 1 Mar 1986
Externally published	Yes

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title = "Trace-element levels in tissues of rats and dogs treated with cis-diammine/1,1-cyclobutanedicarboxylato/platinum/II/ /Carboplatin/",

abstract = "Platinum and eleven other trace elements were determined by radiochemical neutron activation analysis in tissues of healthy rats and dogs treated with the anti-cancer drug carboplatin. In rats the levels of the trace elements were not much influenced; in the kidney only the Co and the Sb levels were decreased and in the liver only the Mo level was increased. A parallel tendency in the Co and Mo metabolism was seen in dogs. Carboplatin treatment tends to reduce the Cd, Co and Fe levels in metabolic active organs, kidney, liver, spleen and/or pancreas of the dog.",

author = "Tjioe, {P. S.} and Kroon, {Jacques J.} and P. Lelieveld and {van der Vijgh}, {W. J.F.}",

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T1 - Trace-element levels in tissues of rats and dogs treated with cis-diammine/1,1-cyclobutanedicarboxylato/platinum/II/ /Carboplatin/

AU - Tjioe, P. S.

AU - Kroon, Jacques J.

AU - Lelieveld, P.

AU - van der Vijgh, W. J.F.

PY - 1986/3/1

Y1 - 1986/3/1

N2 - Platinum and eleven other trace elements were determined by radiochemical neutron activation analysis in tissues of healthy rats and dogs treated with the anti-cancer drug carboplatin. In rats the levels of the trace elements were not much influenced; in the kidney only the Co and the Sb levels were decreased and in the liver only the Mo level was increased. A parallel tendency in the Co and Mo metabolism was seen in dogs. Carboplatin treatment tends to reduce the Cd, Co and Fe levels in metabolic active organs, kidney, liver, spleen and/or pancreas of the dog.

AB - Platinum and eleven other trace elements were determined by radiochemical neutron activation analysis in tissues of healthy rats and dogs treated with the anti-cancer drug carboplatin. In rats the levels of the trace elements were not much influenced; in the kidney only the Co and the Sb levels were decreased and in the liver only the Mo level was increased. A parallel tendency in the Co and Mo metabolism was seen in dogs. Carboplatin treatment tends to reduce the Cd, Co and Fe levels in metabolic active organs, kidney, liver, spleen and/or pancreas of the dog.

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AN - SCOPUS:0022518314

SN - 0236-5731

VL - 104

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JO - Journal of Radioanalytical and Nuclear Chemistry

JF - Journal of Radioanalytical and Nuclear Chemistry

IS - 2

ER -

Trace-element levels in tissues of rats and dogs treated with cis-diammine/1,1-cyclobutanedicarboxylato/platinum/II/ /Carboplatin/

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