Towards ultrahigh resolution OCT based endoscopical pituitary gland and adenoma screening: a performance parameter evaluation

Fabian Placzek (Corresponding author), Alexander Micko, Ryan Sentosa, Roger Fonollà, Michael Winklehner, Arthur Hosmann, Marco Andreana, Romana Höftberger, Wolfgang Drexler, Rainer A. Leitgeb, Stefan Wolfsberger, Angelika Unterhuber

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Ultrahigh resolution optical coherence tomography (UHR-OCT) for differentiating pituitary gland versus adenoma tissue has been investigated for the first time, indicating more than 80% accuracy. For biomarker identification, OCT images of paraffin embedded tissue are correlated to histopathological slices. The identified biomarkers are verified on fresh biopsies. Additionally, an approach, based on resolution modified UHR-OCT ex vivo data, investigating optical performance parameters for the realization in an in vivo endoscope is presented and evaluated. The identified morphological features–cell groups with reticulin framework–detectable with UHR-OCT showcase a promising differentiation ability, encouraging endoscopic OCT probe development for in vivo application.

Original languageEnglish
Pages (from-to)7003-7018
Number of pages16
JournalBiomedical Optics Express
Volume11
Issue number12
DOIs
Publication statusPublished - 1 Dec 2020

Keywords

  • Biomarkers
  • Brain
  • Coherent light
  • Endoscopy
  • Tumors
  • Optical tomography

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