Towards ultrahigh resolution OCT based endoscopical pituitary gland and adenoma screening: a performance parameter evaluation

Fabian Placzek; Alexander Micko; Ryan Sentosa; Roger Fonollà; Michael Winklehner; Arthur Hosmann; Marco Andreana; Romana Höftberger; Wolfgang Drexler; Rainer A. Leitgeb; Stefan Wolfsberger; Angelika Unterhuber

doi:10.1364/BOE.409987

Towards ultrahigh resolution OCT based endoscopical pituitary gland and adenoma screening: a performance parameter evaluation

Fabian Placzek (Corresponding author), Alexander Micko, Ryan Sentosa, Roger Fonollà, Michael Winklehner, Arthur Hosmann, Marco Andreana, Romana Höftberger, Wolfgang Drexler, Rainer A. Leitgeb, Stefan Wolfsberger, Angelika Unterhuber

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Abstract

Ultrahigh resolution optical coherence tomography (UHR-OCT) for differentiating pituitary gland versus adenoma tissue has been investigated for the first time, indicating more than 80% accuracy. For biomarker identification, OCT images of paraffin embedded tissue are correlated to histopathological slices. The identified biomarkers are verified on fresh biopsies. Additionally, an approach, based on resolution modified UHR-OCT ex vivo data, investigating optical performance parameters for the realization in an in vivo endoscope is presented and evaluated. The identified morphological features–cell groups with reticulin framework–detectable with UHR-OCT showcase a promising differentiation ability, encouraging endoscopic OCT probe development for in vivo application.

Original language	English
Pages (from-to)	7003-7018
Number of pages	16
Journal	Biomedical Optics Express
Volume	11
Issue number	12
DOIs	https://doi.org/10.1364/BOE.409987
Publication status	Published - 1 Dec 2020

Keywords

Biomarkers
Brain
Coherent light
Endoscopy
Tumors
Optical tomography

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10.1364/BOE.409987

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Placzek, F., Micko, A., Sentosa, R., Fonollà, R., Winklehner, M., Hosmann, A., Andreana, M., Höftberger, R., Drexler, W., Leitgeb, R. A., Wolfsberger, S., & Unterhuber, A. (2020). Towards ultrahigh resolution OCT based endoscopical pituitary gland and adenoma screening: a performance parameter evaluation. Biomedical Optics Express, 11(12), 7003-7018. https://doi.org/10.1364/BOE.409987

Placzek, Fabian ; Micko, Alexander ; Sentosa, Ryan ; Fonollà, Roger ; Winklehner, Michael ; Hosmann, Arthur ; Andreana, Marco ; Höftberger, Romana ; Drexler, Wolfgang ; Leitgeb, Rainer A. ; Wolfsberger, Stefan ; Unterhuber, Angelika. / Towards ultrahigh resolution OCT based endoscopical pituitary gland and adenoma screening: a performance parameter evaluation. In: Biomedical Optics Express. 2020 ; Vol. 11, No. 12. pp. 7003-7018.

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abstract = "Ultrahigh resolution optical coherence tomography (UHR-OCT) for differentiating pituitary gland versus adenoma tissue has been investigated for the first time, indicating more than 80% accuracy. For biomarker identification, OCT images of paraffin embedded tissue are correlated to histopathological slices. The identified biomarkers are verified on fresh biopsies. Additionally, an approach, based on resolution modified UHR-OCT ex vivo data, investigating optical performance parameters for the realization in an in vivo endoscope is presented and evaluated. The identified morphological features–cell groups with reticulin framework–detectable with UHR-OCT showcase a promising differentiation ability, encouraging endoscopic OCT probe development for in vivo application.",

keywords = "Biomarkers, Brain, Coherent light, Endoscopy, Tumors, Optical tomography",

author = "Fabian Placzek and Alexander Micko and Ryan Sentosa and Roger Fonoll{\`a} and Michael Winklehner and Arthur Hosmann and Marco Andreana and Romana H{\"o}ftberger and Wolfgang Drexler and Leitgeb, {Rainer A.} and Stefan Wolfsberger and Angelika Unterhuber",

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Placzek, F, Micko, A, Sentosa, R, Fonollà, R, Winklehner, M, Hosmann, A, Andreana, M, Höftberger, R, Drexler, W, Leitgeb, RA, Wolfsberger, S & Unterhuber, A 2020, 'Towards ultrahigh resolution OCT based endoscopical pituitary gland and adenoma screening: a performance parameter evaluation', Biomedical Optics Express, vol. 11, no. 12, pp. 7003-7018. https://doi.org/10.1364/BOE.409987

Towards ultrahigh resolution OCT based endoscopical pituitary gland and adenoma screening: a performance parameter evaluation. / Placzek, Fabian (Corresponding author); Micko, Alexander; Sentosa, Ryan; Fonollà, Roger; Winklehner, Michael; Hosmann, Arthur; Andreana, Marco; Höftberger, Romana; Drexler, Wolfgang; Leitgeb, Rainer A.; Wolfsberger, Stefan; Unterhuber, Angelika.

In: Biomedical Optics Express, Vol. 11, No. 12, 01.12.2020, p. 7003-7018.

Research output: Contribution to journal › Article › Academic › peer-review

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