Abstract
Ultrahigh resolution optical coherence tomography (UHR-OCT) for differentiating pituitary gland versus adenoma tissue has been investigated for the first time, indicating more than 80% accuracy. For biomarker identification, OCT images of paraffin embedded tissue are correlated to histopathological slices. The identified biomarkers are verified on fresh biopsies. Additionally, an approach, based on resolution modified UHR-OCT ex vivo data, investigating optical performance parameters for the realization in an in vivo endoscope is presented and evaluated. The identified morphological features–cell groups with reticulin framework–detectable with UHR-OCT showcase a promising differentiation ability, encouraging endoscopic OCT probe development for in vivo application.
Original language | English |
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Pages (from-to) | 7003-7018 |
Number of pages | 16 |
Journal | Biomedical Optics Express |
Volume | 11 |
Issue number | 12 |
DOIs | |
Publication status | Published - 1 Dec 2020 |
Keywords
- Biomarkers
- Brain
- Coherent light
- Endoscopy
- Tumors
- Optical tomography