Towards in vivo photoacoustic imaging of vulnerable plaques in the carotid artery

Jan-Willem Muller (Corresponding author), Roy P.M. van Hees, Marc R.H.M. van Sambeek, Pierre Boutouyrie, Marcel C.M. Rutten, Peter Brands, Min Wu, Richard G.P. Lopata

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)
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Abstract

The main indicator for endarterectomy is the grade of stenosis, which results in severe overtreatment. Photoacoustic imaging (PAI) can provide patient-specific assessment of plaque morphology, and thereby vulnerability. A pilot study of PAI on carotid plaques in patients (n=16) was performed intraoperatively with a hand-held PAI system. By compensating for motion, the photoacoustic (PA) signal-to-noise ratio (SNR) could be increased by 5 dB in vivo. PA signals from hemorrhagic plaques had different characteristics compared to the signals from the carotid blood pool. This study is a key step towards a non-invasive application of PAI to detect vulnerable plaques.
Original languageEnglish
Pages (from-to)4207-4218
Number of pages12
JournalBiomedical Optics Express
Volume12
Issue number7
DOIs
Publication statusPublished - 1 Jul 2021

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