TY - JOUR
T1 - Towards a personalised approach in exercise-based cardiovascular rehabilitation
T2 - How can translational research help? A 'call to action' from the Section on Secondary Prevention and Cardiac Rehabilitation of the European Association of Preventive Cardiology
AU - Gevaert, Andreas B
AU - Adams, Volker
AU - Bahls, Martin
AU - Bowen, T Scott
AU - Cornelissen, Veronique
AU - Dörr, Marcus
AU - Hansen, Dominique
AU - Kemps, Hareld Mc
AU - Leeson, Paul
AU - Van Craenenbroeck, Emeline M
AU - Kränkel, Nicolle
PY - 2020/9/1
Y1 - 2020/9/1
N2 - The benefit of regular physical activity and exercise training for the prevention of cardiovascular and metabolic diseases is undisputed. Many molecular mechanisms mediating exercise effects have been deciphered. Personalised exercise prescription can help patients in achieving their individual greatest benefit from an exercise-based cardiovascular rehabilitation programme. Yet, we still struggle to provide truly personalised exercise prescriptions to our patients. In this position paper, we address novel basic and translational research concepts that can help us understand the principles underlying the inter-individual differences in the response to exercise, and identify early on who would most likely benefit from which exercise intervention. This includes hereditary, non-hereditary and sex-specific concepts. Recent insights have helped us to take on a more holistic view, integrating exercise-mediated molecular mechanisms with those influenced by metabolism and immunity. Unfortunately, while the outline is recognisable, many details are still lacking to turn the understanding of a concept into a roadmap ready to be used in clinical routine. This position paper therefore also investigates perspectives on how the advent of 'big data' and the use of animal models could help unravel inter-individual responses to exercise parameters and thus influence hypothesis-building for translational research in exercise-based cardiovascular rehabilitation.
AB - The benefit of regular physical activity and exercise training for the prevention of cardiovascular and metabolic diseases is undisputed. Many molecular mechanisms mediating exercise effects have been deciphered. Personalised exercise prescription can help patients in achieving their individual greatest benefit from an exercise-based cardiovascular rehabilitation programme. Yet, we still struggle to provide truly personalised exercise prescriptions to our patients. In this position paper, we address novel basic and translational research concepts that can help us understand the principles underlying the inter-individual differences in the response to exercise, and identify early on who would most likely benefit from which exercise intervention. This includes hereditary, non-hereditary and sex-specific concepts. Recent insights have helped us to take on a more holistic view, integrating exercise-mediated molecular mechanisms with those influenced by metabolism and immunity. Unfortunately, while the outline is recognisable, many details are still lacking to turn the understanding of a concept into a roadmap ready to be used in clinical routine. This position paper therefore also investigates perspectives on how the advent of 'big data' and the use of animal models could help unravel inter-individual responses to exercise parameters and thus influence hypothesis-building for translational research in exercise-based cardiovascular rehabilitation.
KW - animal models
KW - big data
KW - Cardiovascular rehabilitation
KW - exercise
KW - immune system
KW - machine learning
KW - personalised medicine
KW - responders/non-responders
KW - Cardiac Rehabilitation/methods
KW - Europe
KW - Humans
KW - Translational Medical Research
KW - Secondary Prevention/methods
KW - Societies, Medical
KW - Exercise Therapy/methods
KW - Cardiology
UR - http://www.scopus.com/inward/record.url?scp=85074403808&partnerID=8YFLogxK
U2 - 10.1177/2047487319877716
DO - 10.1177/2047487319877716
M3 - Article
C2 - 31581819
SN - 2047-4873
VL - 27
SP - 1369
EP - 1385
JO - European Journal of Preventive Cardiology
JF - European Journal of Preventive Cardiology
IS - 13
ER -