Toward Gradient Formation in Microfluidic Devices by using Slanted Ridges

T. Schijndel, van, M.K. Singh, M.F. Gillies, N. Kahya, A. Kharin, J.M.J. Toonder, den

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

Some lab-on-a-chip applications require to establish a controlled spatial concentration gradient of (chemical) species, for example for iso-electrical focusing or to study chemotactic properties of cells. We show that covering a microchannel floor with special grooves or ridges, well-controlled concentration gradients can be created, depending on the geometrical design of the grooves or ridges. In our case, the pattern consists of ridges that are slanted with respect to the main channel direction. Similar patterns have been applied in the past to achieve mixing by introducing chaotic advection. We present experimental and numerical results that prove the mixing effectiveness of the ridges. In addition, making use of the local mixing capabilities of theridge patterns, we show, using numerical simulations, how to achieve a concentration gradient across a microfluidic channel.
Original languageEnglish
Pages (from-to)373-379
JournalMacromolecular Materials and Engineering
Volume296
Issue number3-4
DOIs
Publication statusPublished - 2011

Fingerprint

Microfluidics
Lab-on-a-chip
Advection
Microchannels
Computer simulation

Cite this

Schijndel, van, T. ; Singh, M.K. ; Gillies, M.F. ; Kahya, N. ; Kharin, A. ; Toonder, den, J.M.J. / Toward Gradient Formation in Microfluidic Devices by using Slanted Ridges. In: Macromolecular Materials and Engineering. 2011 ; Vol. 296, No. 3-4. pp. 373-379.
@article{3ca43a67df244662b0111f3786b53d59,
title = "Toward Gradient Formation in Microfluidic Devices by using Slanted Ridges",
abstract = "Some lab-on-a-chip applications require to establish a controlled spatial concentration gradient of (chemical) species, for example for iso-electrical focusing or to study chemotactic properties of cells. We show that covering a microchannel floor with special grooves or ridges, well-controlled concentration gradients can be created, depending on the geometrical design of the grooves or ridges. In our case, the pattern consists of ridges that are slanted with respect to the main channel direction. Similar patterns have been applied in the past to achieve mixing by introducing chaotic advection. We present experimental and numerical results that prove the mixing effectiveness of the ridges. In addition, making use of the local mixing capabilities of theridge patterns, we show, using numerical simulations, how to achieve a concentration gradient across a microfluidic channel.",
author = "{Schijndel, van}, T. and M.K. Singh and M.F. Gillies and N. Kahya and A. Kharin and {Toonder, den}, J.M.J.",
year = "2011",
doi = "10.1002/mame.201000264",
language = "English",
volume = "296",
pages = "373--379",
journal = "Macromolecular Materials and Engineering",
issn = "1438-7492",
publisher = "Wiley-VCH Verlag",
number = "3-4",

}

Toward Gradient Formation in Microfluidic Devices by using Slanted Ridges. / Schijndel, van, T.; Singh, M.K.; Gillies, M.F.; Kahya, N.; Kharin, A.; Toonder, den, J.M.J.

In: Macromolecular Materials and Engineering, Vol. 296, No. 3-4, 2011, p. 373-379.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Toward Gradient Formation in Microfluidic Devices by using Slanted Ridges

AU - Schijndel, van, T.

AU - Singh, M.K.

AU - Gillies, M.F.

AU - Kahya, N.

AU - Kharin, A.

AU - Toonder, den, J.M.J.

PY - 2011

Y1 - 2011

N2 - Some lab-on-a-chip applications require to establish a controlled spatial concentration gradient of (chemical) species, for example for iso-electrical focusing or to study chemotactic properties of cells. We show that covering a microchannel floor with special grooves or ridges, well-controlled concentration gradients can be created, depending on the geometrical design of the grooves or ridges. In our case, the pattern consists of ridges that are slanted with respect to the main channel direction. Similar patterns have been applied in the past to achieve mixing by introducing chaotic advection. We present experimental and numerical results that prove the mixing effectiveness of the ridges. In addition, making use of the local mixing capabilities of theridge patterns, we show, using numerical simulations, how to achieve a concentration gradient across a microfluidic channel.

AB - Some lab-on-a-chip applications require to establish a controlled spatial concentration gradient of (chemical) species, for example for iso-electrical focusing or to study chemotactic properties of cells. We show that covering a microchannel floor with special grooves or ridges, well-controlled concentration gradients can be created, depending on the geometrical design of the grooves or ridges. In our case, the pattern consists of ridges that are slanted with respect to the main channel direction. Similar patterns have been applied in the past to achieve mixing by introducing chaotic advection. We present experimental and numerical results that prove the mixing effectiveness of the ridges. In addition, making use of the local mixing capabilities of theridge patterns, we show, using numerical simulations, how to achieve a concentration gradient across a microfluidic channel.

U2 - 10.1002/mame.201000264

DO - 10.1002/mame.201000264

M3 - Article

VL - 296

SP - 373

EP - 379

JO - Macromolecular Materials and Engineering

JF - Macromolecular Materials and Engineering

SN - 1438-7492

IS - 3-4

ER -