Topology characterization by MALDI-ToF-MS of enzymatically synthesized poly(lactide-co-glycolide)

S. Huijser; B.B.P. Staal; Juan Huang; R. Duchateau; C.E. Koning

doi:10.1021/bm060466v

Topology characterization by MALDI-ToF-MS of enzymatically synthesized poly(lactide-co-glycolide)

S. Huijser
, B.B.P. Staal
, Juan Huang
, R. Duchateau
, C.E. Koning

Chemical Engineering and Chemistry

Research output: Contribution to journal › Article › Academic › peer-review

58 Citations (Scopus)

Abstract

Lipase catalyzed copolymerization of the monomers lactide and glycolide by Pseudomonas cepacia employing a molar ratio of 80L/20G has been studied. The copolymers were characterized by MALDI-ToF-MS, DSC, SEC and NMR. MALDI-ToF-MS has successfully been used not only to determine end groups and chemical composition but even the microstructure of the copolymers. We demonstrated that for this lipase catalyzed copolymerization, the main product of the reaction at 100 °C was linear homopolymer of lactide while at 130 °C the main product was cyclic random copolymer.

Original language	English
Pages (from-to)	2465-2469
Number of pages	5
Journal	Biomacromolecules
Volume	7
Issue number	9
DOIs	https://doi.org/10.1021/bm060466v
Publication status	Published - 2006

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title = "Topology characterization by MALDI-ToF-MS of enzymatically synthesized poly(lactide-co-glycolide)",

abstract = "Lipase catalyzed copolymerization of the monomers lactide and glycolide by Pseudomonas cepacia employing a molar ratio of 80L/20G has been studied. The copolymers were characterized by MALDI-ToF-MS, DSC, SEC and NMR. MALDI-ToF-MS has successfully been used not only to determine end groups and chemical composition but even the microstructure of the copolymers. We demonstrated that for this lipase catalyzed copolymerization, the main product of the reaction at 100 °C was linear homopolymer of lactide while at 130 °C the main product was cyclic random copolymer.",

author = "S. Huijser and B.B.P. Staal and Juan Huang and R. Duchateau and C.E. Koning",

year = "2006",

doi = "10.1021/bm060466v",

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T1 - Topology characterization by MALDI-ToF-MS of enzymatically synthesized poly(lactide-co-glycolide)

AU - Huijser, S.

AU - Staal, B.B.P.

AU - Huang, Juan

AU - Duchateau, R.

AU - Koning, C.E.

PY - 2006

Y1 - 2006

N2 - Lipase catalyzed copolymerization of the monomers lactide and glycolide by Pseudomonas cepacia employing a molar ratio of 80L/20G has been studied. The copolymers were characterized by MALDI-ToF-MS, DSC, SEC and NMR. MALDI-ToF-MS has successfully been used not only to determine end groups and chemical composition but even the microstructure of the copolymers. We demonstrated that for this lipase catalyzed copolymerization, the main product of the reaction at 100 °C was linear homopolymer of lactide while at 130 °C the main product was cyclic random copolymer.

AB - Lipase catalyzed copolymerization of the monomers lactide and glycolide by Pseudomonas cepacia employing a molar ratio of 80L/20G has been studied. The copolymers were characterized by MALDI-ToF-MS, DSC, SEC and NMR. MALDI-ToF-MS has successfully been used not only to determine end groups and chemical composition but even the microstructure of the copolymers. We demonstrated that for this lipase catalyzed copolymerization, the main product of the reaction at 100 °C was linear homopolymer of lactide while at 130 °C the main product was cyclic random copolymer.

U2 - 10.1021/bm060466v

DO - 10.1021/bm060466v

M3 - Article

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SN - 1525-7797

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SP - 2465

EP - 2469

JO - Biomacromolecules

JF - Biomacromolecules

IS - 9

ER -

Topology characterization by MALDI-ToF-MS of enzymatically synthesized poly(lactide-co-glycolide)

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