TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide–alkyne cycloaddition reactions

Jimmy Weterings; Cristianne J.F. Rijcken; Harald Veldhuis; Tommi Meulemans; Darya Hadavi; Matt Timmers; Maarten Honing; Hans Ippel; Rob M.J. Liskamp

doi:10.1039/D0SC03477K

TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide–alkyne cycloaddition reactions

Jimmy Weterings, Cristianne J.F. Rijcken, Harald Veldhuis, Tommi Meulemans, Darya Hadavi, Matt Timmers, Maarten Honing, Hans Ippel, Rob M.J. Liskamp

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Abstract

We describe the development of TMTH-SulfoxImine (TMTHSI) as a superior click reagent. This reagent combines a great reactivity, with small size and low hydrophobicity and compares outstandingly with existing click reagents. TMTHSI can be conveniently functionalized with a variety of linkers allowing attachment of a diversity of small molecules and (peptide, nucleic acid) biologics.

Original language	English
Pages (from-to)	9011-9016
Number of pages	6
Journal	Chemical Science
Volume	11
Issue number	33
DOIs	https://doi.org/10.1039/D0SC03477K
Publication status	Published - 7 Sept 2020
Externally published	Yes

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title = "TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide–alkyne cycloaddition reactions",

abstract = "We describe the development of TMTH-SulfoxImine (TMTHSI) as a superior click reagent. This reagent combines a great reactivity, with small size and low hydrophobicity and compares outstandingly with existing click reagents. TMTHSI can be conveniently functionalized with a variety of linkers allowing attachment of a diversity of small molecules and (peptide, nucleic acid) biologics.",

author = "Jimmy Weterings and Rijcken, {Cristianne J.F.} and Harald Veldhuis and Tommi Meulemans and Darya Hadavi and Matt Timmers and Maarten Honing and Hans Ippel and Liskamp, {Rob M.J.}",

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doi = "10.1039/D0SC03477K",

language = "English",

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T1 - TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide–alkyne cycloaddition reactions

AU - Weterings, Jimmy

AU - Rijcken, Cristianne J.F.

AU - Veldhuis, Harald

AU - Meulemans, Tommi

AU - Hadavi, Darya

AU - Timmers, Matt

AU - Honing, Maarten

AU - Ippel, Hans

AU - Liskamp, Rob M.J.

PY - 2020/9/7

Y1 - 2020/9/7

N2 - We describe the development of TMTH-SulfoxImine (TMTHSI) as a superior click reagent. This reagent combines a great reactivity, with small size and low hydrophobicity and compares outstandingly with existing click reagents. TMTHSI can be conveniently functionalized with a variety of linkers allowing attachment of a diversity of small molecules and (peptide, nucleic acid) biologics.

AB - We describe the development of TMTH-SulfoxImine (TMTHSI) as a superior click reagent. This reagent combines a great reactivity, with small size and low hydrophobicity and compares outstandingly with existing click reagents. TMTHSI can be conveniently functionalized with a variety of linkers allowing attachment of a diversity of small molecules and (peptide, nucleic acid) biologics.

UR - http://www.scopus.com/inward/record.url?scp=85092409237&partnerID=8YFLogxK

U2 - 10.1039/D0SC03477K

DO - 10.1039/D0SC03477K

M3 - Article

SN - 2041-6520

VL - 11

SP - 9011

EP - 9016

JO - Chemical Science

JF - Chemical Science

IS - 33

ER -

TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide–alkyne cycloaddition reactions

Abstract

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