Tissue models

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Abstract

The hypes and hopes of tissue engineering and associated efforts of researchers to succeed in this area have resulted in many attempts to produce living tissue and organs outside the human body. These include the creation of skin, cartilage, bone, tendon, skeletal muscles, heart muscle, blood vessels, heart valves and bladder tissue, in which the degree of success is mainly evaluated on the basis of structural similarities with native or ‘the original’ human tissue. Despite their envisioned and highly recommended potential as tissue replacements inside the human body, many of these types of tissue still only function outside the human body and have not passed the stage of laboratory prototype or small-scale implantation studies in animals. Thus, the broad-scale clinical application of tissue engineered products lies far ahead and, apart from commercial and regulatory problems, very much depends on scientific progress.Notwithstanding these drawbacks, a decade of intensive and interdisciplinary research, converging knowledge from biology, material science, bioengineering and medicine, has brought scientific and technological progress in the field of regenerative medicine. In line with all this, a more immediate and directly assessable application of tissue engineering has been the creation of three-dimensional (3-D) laboratory models of tissues and organs. Even in those areas where clinically relevant tissues are decades away, the tissues that are currently being made provide powerful ‘living’ biological models. These 3-D models are far more realistic than existing two-dimensional (2-D) cell culture models and can be used to study or test a specific aspect of interest at tissue level with a higher level of experimental control and with less ethical considerations than animal models. Tissue model systems find their application in studying normal and pathological tissue functioning and the associated testing of potential therapies. In addition, they represent useful tools for the development of technologies for regenerative medicine and early diagnosis and tissue screening
Original languageEnglish
Title of host publicationConverging technologies: innovation patterns and impacts on society
EditorsM. Doorn
PublisherSTT Netherlands, Study Centre for Technology Trends
Pages118-132
ISBN (Print)978-90-809613-3-3
Publication statusPublished - 2006

Publication series

NameStichting Toekomstbeeld der Techniek
Volume71

Fingerprint

Human Body
Regenerative Medicine
Tissue Engineering
Bioengineering
Somatotypes
Biological Models
Somatostatin-Secreting Cells
Heart Valves
Tendons
Cartilage
Blood Vessels
Early Diagnosis
Myocardium
Skeletal Muscle
Urinary Bladder
Animal Models
Cell Culture Techniques
Research Personnel
Medicine
Technology

Cite this

Bouten, C. V. C. (2006). Tissue models. In M. Doorn (Ed.), Converging technologies: innovation patterns and impacts on society (pp. 118-132). (Stichting Toekomstbeeld der Techniek; Vol. 71). STT Netherlands, Study Centre for Technology Trends.
Bouten, C.V.C. / Tissue models. Converging technologies: innovation patterns and impacts on society. editor / M. Doorn. STT Netherlands, Study Centre for Technology Trends, 2006. pp. 118-132 (Stichting Toekomstbeeld der Techniek).
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Bouten, CVC 2006, Tissue models. in M Doorn (ed.), Converging technologies: innovation patterns and impacts on society. Stichting Toekomstbeeld der Techniek, vol. 71, STT Netherlands, Study Centre for Technology Trends, pp. 118-132.

Tissue models. / Bouten, C.V.C.

Converging technologies: innovation patterns and impacts on society. ed. / M. Doorn. STT Netherlands, Study Centre for Technology Trends, 2006. p. 118-132 (Stichting Toekomstbeeld der Techniek; Vol. 71).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

TY - CHAP

T1 - Tissue models

AU - Bouten, C.V.C.

PY - 2006

Y1 - 2006

N2 - The hypes and hopes of tissue engineering and associated efforts of researchers to succeed in this area have resulted in many attempts to produce living tissue and organs outside the human body. These include the creation of skin, cartilage, bone, tendon, skeletal muscles, heart muscle, blood vessels, heart valves and bladder tissue, in which the degree of success is mainly evaluated on the basis of structural similarities with native or ‘the original’ human tissue. Despite their envisioned and highly recommended potential as tissue replacements inside the human body, many of these types of tissue still only function outside the human body and have not passed the stage of laboratory prototype or small-scale implantation studies in animals. Thus, the broad-scale clinical application of tissue engineered products lies far ahead and, apart from commercial and regulatory problems, very much depends on scientific progress.Notwithstanding these drawbacks, a decade of intensive and interdisciplinary research, converging knowledge from biology, material science, bioengineering and medicine, has brought scientific and technological progress in the field of regenerative medicine. In line with all this, a more immediate and directly assessable application of tissue engineering has been the creation of three-dimensional (3-D) laboratory models of tissues and organs. Even in those areas where clinically relevant tissues are decades away, the tissues that are currently being made provide powerful ‘living’ biological models. These 3-D models are far more realistic than existing two-dimensional (2-D) cell culture models and can be used to study or test a specific aspect of interest at tissue level with a higher level of experimental control and with less ethical considerations than animal models. Tissue model systems find their application in studying normal and pathological tissue functioning and the associated testing of potential therapies. In addition, they represent useful tools for the development of technologies for regenerative medicine and early diagnosis and tissue screening

AB - The hypes and hopes of tissue engineering and associated efforts of researchers to succeed in this area have resulted in many attempts to produce living tissue and organs outside the human body. These include the creation of skin, cartilage, bone, tendon, skeletal muscles, heart muscle, blood vessels, heart valves and bladder tissue, in which the degree of success is mainly evaluated on the basis of structural similarities with native or ‘the original’ human tissue. Despite their envisioned and highly recommended potential as tissue replacements inside the human body, many of these types of tissue still only function outside the human body and have not passed the stage of laboratory prototype or small-scale implantation studies in animals. Thus, the broad-scale clinical application of tissue engineered products lies far ahead and, apart from commercial and regulatory problems, very much depends on scientific progress.Notwithstanding these drawbacks, a decade of intensive and interdisciplinary research, converging knowledge from biology, material science, bioengineering and medicine, has brought scientific and technological progress in the field of regenerative medicine. In line with all this, a more immediate and directly assessable application of tissue engineering has been the creation of three-dimensional (3-D) laboratory models of tissues and organs. Even in those areas where clinically relevant tissues are decades away, the tissues that are currently being made provide powerful ‘living’ biological models. These 3-D models are far more realistic than existing two-dimensional (2-D) cell culture models and can be used to study or test a specific aspect of interest at tissue level with a higher level of experimental control and with less ethical considerations than animal models. Tissue model systems find their application in studying normal and pathological tissue functioning and the associated testing of potential therapies. In addition, they represent useful tools for the development of technologies for regenerative medicine and early diagnosis and tissue screening

M3 - Chapter

SN - 978-90-809613-3-3

T3 - Stichting Toekomstbeeld der Techniek

SP - 118

EP - 132

BT - Converging technologies: innovation patterns and impacts on society

A2 - Doorn, M.

PB - STT Netherlands, Study Centre for Technology Trends

ER -

Bouten CVC. Tissue models. In Doorn M, editor, Converging technologies: innovation patterns and impacts on society. STT Netherlands, Study Centre for Technology Trends. 2006. p. 118-132. (Stichting Toekomstbeeld der Techniek).