TY - JOUR
T1 - Tissue assembly and organization
T2 - Developmental mechanisms in microfabricated tissues
AU - Rivron, Nicolas C.
AU - Rouwkema, Jeroen
AU - Truckenmüller, Roman
AU - Karperien, Marcel
AU - De Boer, Jan
AU - Van Blitterswijk, Clemens A.
PY - 2009/10/1
Y1 - 2009/10/1
N2 - In vitro-generated tissues hold significant promise in modern biology since they can potentially mimic physiological and pathological tissues. However, these are currently structurally and functionally of limited complexity and necessitate self-organization and recapitulation of tissue development mechanisms in vitro. Tools derived from nano- and microfabrications along with bottom-up strategies are emerging to allow the fabrication of primitive tissues structures that can remodel overtime. Subsequently, clues are accumulating to show that, beyond genetic material, both intrinsic tissue architectures and microenvironmental cues can lead to morphogenesis related mechanisms in vitro. The question arises, however, as how we may design and assemble structures prone to adequate tissue remodeling, predict and manipulate those developmental mechanisms in vitro? Systems integrating architectural, physical and molecular cues will allow more systematic investigation of basic principles of tissue morphogenesis, differentiation or maintenance and will feedback to reproduce the dynamic of tissue development in vitro and form more complex tissues.
AB - In vitro-generated tissues hold significant promise in modern biology since they can potentially mimic physiological and pathological tissues. However, these are currently structurally and functionally of limited complexity and necessitate self-organization and recapitulation of tissue development mechanisms in vitro. Tools derived from nano- and microfabrications along with bottom-up strategies are emerging to allow the fabrication of primitive tissues structures that can remodel overtime. Subsequently, clues are accumulating to show that, beyond genetic material, both intrinsic tissue architectures and microenvironmental cues can lead to morphogenesis related mechanisms in vitro. The question arises, however, as how we may design and assemble structures prone to adequate tissue remodeling, predict and manipulate those developmental mechanisms in vitro? Systems integrating architectural, physical and molecular cues will allow more systematic investigation of basic principles of tissue morphogenesis, differentiation or maintenance and will feedback to reproduce the dynamic of tissue development in vitro and form more complex tissues.
KW - Microscale tissue engineering
KW - Morphogenesis
KW - Self-organization
UR - http://www.scopus.com/inward/record.url?scp=68049106088&partnerID=8YFLogxK
U2 - 10.1016/j.biomaterials.2009.06.037
DO - 10.1016/j.biomaterials.2009.06.037
M3 - Article
C2 - 19592088
AN - SCOPUS:68049106088
VL - 30
SP - 4851
EP - 4858
JO - Biomaterials
JF - Biomaterials
SN - 0142-9612
IS - 28
ER -