Tissue- and cell-level inhomogeneities significantly alter the mechanical behavior of tissue-engineered cartilage

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Abstract

The insufficient load-bearing capacity of today’s tissue engineered (TE) cartilage is an important limiting factor for its clinical application. It is believed that the mechanical quality of TE cartilage constructs would be optimal if it had both a structure and composition resembling native cartilage. Cartilage TE studies therefore aim to reach extracellular matrix (ECM) content that resembles that of native tissue. However, the correlation between ECM content and mechanical properties of TE constructs is not unique and the correlation between matrix content and mechanical properties vary considerably.
Original languageEnglish
Title of host publicationProceedings of the ASME 2012 Summer Bioengineering Conference (SBC 2012), 20-23 June 2012, Fajardo, Puerto Rico
Number of pages2
DOIs
Publication statusPublished - 2012
EventASME 2012 Summer Bioengineering Conference (SBC 2012) - Fajardo, Puerto Rico
Duration: 20 Jun 201223 Jun 2012
http://www.asmeconferences.org/SBC2012/

Conference

ConferenceASME 2012 Summer Bioengineering Conference (SBC 2012)
Abbreviated titleSBC 2012
CountryPuerto Rico
CityFajardo
Period20/06/1223/06/12
Internet address

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  • Cite this

    Khoshgoftar, M., Wilson, W., Ito, K., & Donkelaar, van, C. C. (2012). Tissue- and cell-level inhomogeneities significantly alter the mechanical behavior of tissue-engineered cartilage. In Proceedings of the ASME 2012 Summer Bioengineering Conference (SBC 2012), 20-23 June 2012, Fajardo, Puerto Rico [SBC2012-80758] https://doi.org/10.1115/SBC2012-80758