Tissue- and cell-level inhomogeneities significantly alter the mechanical behavior of tissue-engineered cartilage

M. Khoshgoftar; W. Wilson; K. Ito; C.C. Donkelaar, van

doi:10.1115/SBC2012-80758

Tissue- and cell-level inhomogeneities significantly alter the mechanical behavior of tissue-engineered cartilage

M. Khoshgoftar, W. Wilson, K. Ito, C.C. Donkelaar, van

Orthopaedic Biomechanics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

The insufficient load-bearing capacity of today’s tissue engineered (TE) cartilage is an important limiting factor for its clinical application. It is believed that the mechanical quality of TE cartilage constructs would be optimal if it had both a structure and composition resembling native cartilage. Cartilage TE studies therefore aim to reach extracellular matrix (ECM) content that resembles that of native tissue. However, the correlation between ECM content and mechanical properties of TE constructs is not unique and the correlation between matrix content and mechanical properties vary considerably.

Original language	English
Title of host publication	Proceedings of the ASME 2012 Summer Bioengineering Conference (SBC 2012), 20-23 June 2012, Fajardo, Puerto Rico
Number of pages	2
DOIs	https://doi.org/10.1115/SBC2012-80758
Publication status	Published - 2012
Event	ASME 2012 Summer Bioengineering Conference (SBC 2012) - Fajardo, Puerto Rico Duration: 20 Jun 2012 → 23 Jun 2012 http://www.asmeconferences.org/SBC2012/

Conference

Conference	ASME 2012 Summer Bioengineering Conference (SBC 2012)
Abbreviated title	SBC 2012
Country/Territory	Puerto Rico
City	Fajardo
Period	20/06/12 → 23/06/12
Internet address	http://www.asmeconferences.org/SBC2012/

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10.1115/SBC2012-80758

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title = "Tissue- and cell-level inhomogeneities significantly alter the mechanical behavior of tissue-engineered cartilage",

abstract = "The insufficient load-bearing capacity of today{\textquoteright}s tissue engineered (TE) cartilage is an important limiting factor for its clinical application. It is believed that the mechanical quality of TE cartilage constructs would be optimal if it had both a structure and composition resembling native cartilage. Cartilage TE studies therefore aim to reach extracellular matrix (ECM) content that resembles that of native tissue. However, the correlation between ECM content and mechanical properties of TE constructs is not unique and the correlation between matrix content and mechanical properties vary considerably.",

author = "M. Khoshgoftar and W. Wilson and K. Ito and {Donkelaar, van}, C.C.",

year = "2012",

doi = "10.1115/SBC2012-80758",

language = "English",

booktitle = "Proceedings of the ASME 2012 Summer Bioengineering Conference (SBC 2012), 20-23 June 2012, Fajardo, Puerto Rico",

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}

Khoshgoftar, M, Wilson, W , Ito, K & Donkelaar, van, CC 2012, Tissue- and cell-level inhomogeneities significantly alter the mechanical behavior of tissue-engineered cartilage. in Proceedings of the ASME 2012 Summer Bioengineering Conference (SBC 2012), 20-23 June 2012, Fajardo, Puerto Rico., SBC2012-80758, ASME 2012 Summer Bioengineering Conference (SBC 2012), Fajardo, Puerto Rico, 20/06/12. https://doi.org/10.1115/SBC2012-80758

Tissue- and cell-level inhomogeneities significantly alter the mechanical behavior of tissue-engineered cartilage. / Khoshgoftar, M.; Wilson, W.; Ito, K.; Donkelaar, van, C.C.

Proceedings of the ASME 2012 Summer Bioengineering Conference (SBC 2012), 20-23 June 2012, Fajardo, Puerto Rico. 2012. SBC2012-80758.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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N2 - The insufficient load-bearing capacity of today’s tissue engineered (TE) cartilage is an important limiting factor for its clinical application. It is believed that the mechanical quality of TE cartilage constructs would be optimal if it had both a structure and composition resembling native cartilage. Cartilage TE studies therefore aim to reach extracellular matrix (ECM) content that resembles that of native tissue. However, the correlation between ECM content and mechanical properties of TE constructs is not unique and the correlation between matrix content and mechanical properties vary considerably.

AB - The insufficient load-bearing capacity of today’s tissue engineered (TE) cartilage is an important limiting factor for its clinical application. It is believed that the mechanical quality of TE cartilage constructs would be optimal if it had both a structure and composition resembling native cartilage. Cartilage TE studies therefore aim to reach extracellular matrix (ECM) content that resembles that of native tissue. However, the correlation between ECM content and mechanical properties of TE constructs is not unique and the correlation between matrix content and mechanical properties vary considerably.

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DO - 10.1115/SBC2012-80758

M3 - Conference contribution

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T2 - ASME 2012 Summer Bioengineering Conference (SBC 2012)

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ER -

Tissue- and cell-level inhomogeneities significantly alter the mechanical behavior of tissue-engineered cartilage

Abstract

Conference

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