Time-dependent ligand current into a saturating cell performing chemoreception

B.J. Geurts, F.W. Wiegel

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Abstract

We determine the ligand current into a single spherical cell whose receptors become permanently blocked after binding ligands. Initially the cell is placed in a medium which contains ligands at uniform concentration. The analytical solution for the ligand distribution is obtained in terms of an integral over the solution at the cell surface. For the solution at the cell surface a nonlinear integral equation is derived which is solved numerically. We determine the time-dependent ligand current into the cell and the average number of free receptors in the cell surface as a function of time
Original languageEnglish
Pages (from-to)317-324
JournalBiophysical Chemistry
Volume31
Issue number3
DOIs
Publication statusPublished - 1988

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Ligands
Cell Surface Receptors
Integral equations
Cell Count

Cite this

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Time-dependent ligand current into a saturating cell performing chemoreception. / Geurts, B.J.; Wiegel, F.W.

In: Biophysical Chemistry, Vol. 31, No. 3, 1988, p. 317-324.

Research output: Contribution to journalArticleAcademicpeer-review

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AB - We determine the ligand current into a single spherical cell whose receptors become permanently blocked after binding ligands. Initially the cell is placed in a medium which contains ligands at uniform concentration. The analytical solution for the ligand distribution is obtained in terms of an integral over the solution at the cell surface. For the solution at the cell surface a nonlinear integral equation is derived which is solved numerically. We determine the time-dependent ligand current into the cell and the average number of free receptors in the cell surface as a function of time

U2 - 10.1016/0301-4622(88)80038-3

DO - 10.1016/0301-4622(88)80038-3

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VL - 31

SP - 317

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JF - Biophysical Chemistry

SN - 0301-4622

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