Three-dimensional quantification of regional left-ventricular dyssynchrony by magnetic resonance imaging

M. Mischi, F. Kaklidou, P. Houthuizen, J.P. Aben, F.W. Prinzen, F. Bracke, H. van den Bosch, H.H.M. Korsten

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

2 Citations (Scopus)

Abstract

Heart failure accounts for over five million patients in the United States alone. Many of them present dyssynchronous left ventricular (LV) contraction, whose treatment by cardiac resynchronization therapy (CRT) is until now guided by electrocardiographic analysis. One third of the selected patients, however, does not respond to the therapy. Aiming at improving the response rate, recent studies showed the importance of left bundle branch block (LBBB) configurations. Therefore, in order to detect motion patterns that relate to LBBB, this paper presents a novel method for three-dimensional quantification of regional LV mechanical dyssynchrony. LV wall-motion analysis is performed on magnetic resonance imaging (MRI) cines segmented by commercial software. Mutual delays between endocardial wall motion in different LV regions are estimated by cross correlation followed by phase difference analysis in frequency domain, achieving unlimited time resolution. Rather than focusing on the systolic phase, the full cardiac cycle is used to estimate the contraction timing. The method was successfully validated against MRI tagging in five dogs before and after LBBB induction. Preliminary validation in humans with 10 LBBB patients and 7 healthy subjects showed the method feasibility and reproducibility, with sensitivity and specificity in LBBB detection equal to 95.1% and 99.4%, respectively.

Original languageEnglish
Title of host publication33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Place of PublicationPiscataway
PublisherInstitute of Electrical and Electronics Engineers
Pages2646-2649
Number of pages4
ISBN (Electronic)978-1-4577-1589-1
ISBN (Print)978-1-4244-4121-1
DOIs
Publication statusPublished - 26 Dec 2011
Event33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 - Boston, MA, United States
Duration: 30 Aug 20113 Sep 2011

Conference

Conference33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
CountryUnited States
CityBoston, MA
Period30/08/113/09/11

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