Three-dimensional estimation of ultrasound-contrast-agent dispersion and convection in the prostate

R.R. Wildeboer, R.J.G. van Sloun, S.G. Schalk, C.K. Mannaerts, J.C. van der Linden, P. Huang, H. Wijkstra, M. Mischi

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Prostate cancer (PCa) diagnosis still relies on systematic biopsy due to the insufficient reliability of imaging techniques. In this work, we introduce a new method to quantify contrast agent convective dispersion (D) and velocity (v) in a three-dimensional dynamic contrast-enhanced ultrasound (3D DCE-US) recording. First, the concentration gradients of the data are established using Gaussian derivatives in space and time. Assuming D and v to be locally constant, the convective-dispersion equation can then be solved by minimizing a leastsquares problem within a moving 3D kernel. Six PCa patients underwent two-minute 3D DCE-US examination prior to radical prostatectomy. Subsequently, the 3D parametric maps of D and v were compared with the 3D histopathologic data. Preliminary results suggest a good correlation between malignancy according to histopathology and both D and v maps.
Original languageEnglish
Title of host publication2017 IEEE International Ultrasonics Symposium, IUS 2017
Place of PublicationPiscataway
PublisherInstitute of Electrical and Electronics Engineers
Number of pages4
ISBN (Electronic)978-1-5386-3383-0
ISBN (Print)978-1-5386-3384-7
DOIs
Publication statusPublished - 2 Nov 2017
Event2017 IEEE International Ultrasonics Symposium (IUS 2017) - e Omni Shoreham Hotel, Washington, United States
Duration: 6 Sept 20179 Sept 2017
http://ewh.ieee.org/conf/ius/2017/

Conference

Conference2017 IEEE International Ultrasonics Symposium (IUS 2017)
Abbreviated titleIUS 2017
Country/TerritoryUnited States
CityWashington
Period6/09/179/09/17
Internet address

Keywords

  • prostate cancer
  • dynamic contrast-enhanced ultrasound
  • convective-dispersion equation
  • 3D
  • Dynamic contrast-enhanced ultrasound
  • Convective-dispersion equation
  • Prostate cancer

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