Thiophene analogs of estrone; synthesis and structural assignment

A. Corvers, P.C.H. Scheers, J.W. Haan, de, H.M. Buck

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The synthesis of tetracycles of type 1 is described. Both la and lb are converted into the estrogen-like compounds 12a and 12bvia the corresponding a-epoxides. The ß-epoxides yield mixtures of dienes. The stereochemical influence of the base on the alkene precursors for tetracyclic compounds, formed under Wittig-Schlosser conditions, has been established. Finally, evidence is offered for the trans,anti,trans geometry in the tetracyclic molecules under discussion.
Original languageEnglish
Pages (from-to)279-282
JournalRecueil des Travaux Chimiques des Pays-Bas
Issue number11
Publication statusPublished - 1977


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