Thiophene analogs of estrone; synthesis and structural assignment

A. Corvers, P.C.H. Scheers, J.W. Haan, de, H.M. Buck

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)
47 Downloads (Pure)

Abstract

The synthesis of tetracycles of type 1 is described. Both la and lb are converted into the estrogen-like compounds 12a and 12bvia the corresponding a-epoxides. The ß-epoxides yield mixtures of dienes. The stereochemical influence of the base on the alkene precursors for tetracyclic compounds, formed under Wittig-Schlosser conditions, has been established. Finally, evidence is offered for the trans,anti,trans geometry in the tetracyclic molecules under discussion.
Original languageEnglish
Pages (from-to)279-282
JournalRecueil des Travaux Chimiques des Pays-Bas
Volume96
Issue number11
DOIs
Publication statusPublished - 1977

Fingerprint Dive into the research topics of 'Thiophene analogs of estrone; synthesis and structural assignment'. Together they form a unique fingerprint.

Cite this