Therapeutic nanoworms: Towards novel synthetic dendritic cells for immunotherapy

Subhra Mandal, Z.H. Eksteen-Akeroyd, M.J. Jacobs, Roel Hammink, M. Koepf, A.J.A. Lambeck, J.C.M. Hest, van, C.J. Wilson, K. Blank, C.G. Figdor, A.E. Rowan

Research output: Contribution to journalArticleAcademicpeer-review

58 Citations (Scopus)
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Abstract

A new class of antibody-functionalized, semi-flexible and filamentous polymers (diameter 5-10 nm, length ∼200 nm) with a controlled persistence length, a high degree of stereoregularity and the potential for multiple simultaneous receptor interactions has been developed. We have decorated these highly controlled, semi-stiff polymers with T cell activating anti-CD3 antibodies and analyzed their application potential as simple synthetic mimics of dendritic cells (sDCs). Our sDCs do not only activate T cells at significantly lower concentrations than free antibodies or rigid sphere-like counterparts (PLGA particles) but also induce a more robust T cell response. Our novel design further yields sDCs that are biocompatible and non-toxic. The observed increased efficacy highlights the importance of architectural flexibility and multivalency for modulating T cell response and cellular function in general.

Original languageEnglish
Pages (from-to)4168-4174
Number of pages7
JournalChemical Science
Volume4
Issue number11
DOIs
Publication statusPublished - 2013
Externally publishedYes

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