TY - JOUR
T1 - Theoretical models for coronary vascular biomechanics: Progress & challenges
AU - Waters, S.L.
AU - Alastruey, J.
AU - Beard, D.A.
AU - Bovendeerd, P.H.M.
AU - Davies, P.F.
AU - Jayaraman, G.
AU - Jensen, O.E.
AU - Lee, J.
AU - Parker, K.H.
AU - Popel, A.S.
AU - Secomb, T.W.
AU - Siebes, M.
AU - Sherwin, S.J.
AU - Shipley, R.J.
AU - Smith, N.P.
AU - Vosse, van de, F.N.
PY - 2011
Y1 - 2011
N2 - A key aim of the cardiac Physiome Project is to develop theoretical models to simulate the functional behaviour of the heart under physiological and pathophysiological conditions. Heart function is critically dependent on the delivery of an adequate blood supply to the myocardium via the coronary vasculature. Key to this critical function of the coronary vasculature is system dynamics that emerge via the interactions of the numerous constituent components at a range of spatial and temporal scales. Here, we focus on several components for which theoretical approaches can be applied, including vascular structure and mechanics, blood flow and mass transport, flow regulation, angiogenesis and vascular remodelling, and vascular cellular mechanics. For each component, we summarise the current state of the art in model development, and discuss areas requiring further research.We highlight the major challenges associated with integrating the component models to develop a computational tool that can ultimately be used to simulate the responses of the coronary vascular system to changing demands and to diseases and therapies.
AB - A key aim of the cardiac Physiome Project is to develop theoretical models to simulate the functional behaviour of the heart under physiological and pathophysiological conditions. Heart function is critically dependent on the delivery of an adequate blood supply to the myocardium via the coronary vasculature. Key to this critical function of the coronary vasculature is system dynamics that emerge via the interactions of the numerous constituent components at a range of spatial and temporal scales. Here, we focus on several components for which theoretical approaches can be applied, including vascular structure and mechanics, blood flow and mass transport, flow regulation, angiogenesis and vascular remodelling, and vascular cellular mechanics. For each component, we summarise the current state of the art in model development, and discuss areas requiring further research.We highlight the major challenges associated with integrating the component models to develop a computational tool that can ultimately be used to simulate the responses of the coronary vascular system to changing demands and to diseases and therapies.
U2 - 10.1016/j.pbiomolbio.2010.10.001
DO - 10.1016/j.pbiomolbio.2010.10.001
M3 - Article
C2 - 21040741
SN - 0079-6107
VL - 104
SP - 49
EP - 76
JO - Progress in Biophysics and Molecular Biology
JF - Progress in Biophysics and Molecular Biology
IS - 1-3
ER -