The synthesis of phencyclidine and other 1-arylcyclohexylamines

V.H. Maddox, E.F. Godefroi, R.F. Parcell

Research output: Contribution to journalArticleAcademicpeer-review

195 Citations (Scopus)
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Various 1-arylcyclohexylamines were synthesized for evaluation as central nervous system depressants. The compounds were prepared by several procedures. 1-(1-Phenylcyclohexyl)piperidine, the first compound of this type synthesized, was prepared from 1-piperidinocyclohexanecarbonitrile by replacement of the cyano group by phenyl using phenylmagnesium bromide. These compounds were tested for cataleptoid activity and antitonic extensor properties.
Original languageEnglish
Pages (from-to)230-235
Number of pages6
JournalJournal of Medicinal Chemistry
Issue number2
Publication statusPublished - 1965


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