The role of volume transport and near-surface alignment in particled-based target capture.

A. Reenen, van, A.M. Jong, de, M.W.J. Prins

Research output: Contribution to conferencePoster


We investigate the processes that determine the overall association rate in particle-based target capture, i.e. experiments in which bio-functional particles capture biological targets. We describe a theoretical framework and experiments that separate the processes of volume transport, near-surface alignment, and chemical binding. To quantify these processes, different types of actuation are applied, in a model system of fluorescent nanoparticles captured by magnetic microparticles. Compared to passive thermal transport, fluid agitation increases the reaction rate by more than an order of magnitude, implying a higher encounter frequency and a higher near-surface alignment probability. Active rotation of capture particles enhances the near-surface alignment probability per encounter by a factor four. The developed understanding lays the foundation for novel ultra-high-sensitive bioanalytical assay technologies for small sample volumes.
Original languageEnglish
Publication statusPublished - 2013
EventPhysics@FOM Veldhoven 2013 - Koningshof, Veldhoven, Netherlands
Duration: 22 Jan 201323 Jan 2013


ConferencePhysics@FOM Veldhoven 2013

Bibliographical note

Poster at the Physics@FOM Veldhoven, 22-23 januari 2013, Veldhoven, The Netherlands


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