The renaissance of Ras

L.G. Milroy, C. Ottmann

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)
130 Downloads (Pure)

Abstract

Increased signalling by the small G protein Ras is found in many human cancers and is often caused by direct mutation of this protein. Hence, small-molecule attenuation of pathological Ras activity is of utmost interest in oncology. However, despite nearly three decades of intense drug discovery efforts, no clinically viable option for Ras inhibition has been developed. Very recently, reports of a number of new approaches of addressing Ras activity have led to the revival of this molecular target with the prospect of finally fulfilling the therapy promises associated with this important protein.
Original languageEnglish
Pages (from-to)2447-2458
Number of pages12
JournalACS Chemical Biology
Volume9
Issue number11
DOIs
Publication statusPublished - 2014

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