The negative chronotropic effect of adenine derivatives and acetylcholine on frog and rat hearts

A. Versprille; C.D. Duyn, van

doi:10.1007/BF00363197

The negative chronotropic effect of adenine derivatives and acetylcholine on frog and rat hearts

A. Versprille, C.D. Duyn, van

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Abstract

The negative chronotropic effect of ATP on frog as well as rat hearts was not influenced by atropine while the same atropine concentration completely abolished the negative chronotropic effect of Acetylcholine. From these results the conclusion was drawn that the negative chronotropic effect of ATP cannot be ascribed to an acetylcholine release from the efferent vagus fibers. In contrast to Beznák's results we also did not find an acetylcholine releasing activity of ATP on the motor nerve endings in the frog's abdominal muscle.

Original language	English
Pages (from-to)	288-296
Number of pages	9
Journal	Pflügers Archiv fuer die Gesamte Physiologie des Menschen und der Tiere
Volume	292
Issue number	4
DOIs	https://doi.org/10.1007/BF00363197
Publication status	Published - 1966

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title = "The negative chronotropic effect of adenine derivatives and acetylcholine on frog and rat hearts",

abstract = "The negative chronotropic effect of ATP on frog as well as rat hearts was not influenced by atropine while the same atropine concentration completely abolished the negative chronotropic effect of Acetylcholine. From these results the conclusion was drawn that the negative chronotropic effect of ATP cannot be ascribed to an acetylcholine release from the efferent vagus fibers. In contrast to Bezn{\'a}k's results we also did not find an acetylcholine releasing activity of ATP on the motor nerve endings in the frog's abdominal muscle.",

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AU - Duyn, van, C.D.

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AB - The negative chronotropic effect of ATP on frog as well as rat hearts was not influenced by atropine while the same atropine concentration completely abolished the negative chronotropic effect of Acetylcholine. From these results the conclusion was drawn that the negative chronotropic effect of ATP cannot be ascribed to an acetylcholine release from the efferent vagus fibers. In contrast to Beznák's results we also did not find an acetylcholine releasing activity of ATP on the motor nerve endings in the frog's abdominal muscle.

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DO - 10.1007/BF00363197

M3 - Article

SN - 0365-267X

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SP - 288

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JO - Pflügers Archiv fuer die Gesamte Physiologie des Menschen und der Tiere

JF - Pflügers Archiv fuer die Gesamte Physiologie des Menschen und der Tiere

IS - 4

ER -

The negative chronotropic effect of adenine derivatives and acetylcholine on frog and rat hearts

Abstract

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