The negative chronotropic effect of adenine derivatives and acetylcholine on frog and rat hearts

A. Versprille, C.D. Duyn, van

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    Abstract

    The negative chronotropic effect of ATP on frog as well as rat hearts was not influenced by atropine while the same atropine concentration completely abolished the negative chronotropic effect of Acetylcholine. From these results the conclusion was drawn that the negative chronotropic effect of ATP cannot be ascribed to an acetylcholine release from the efferent vagus fibers. In contrast to Beznák's results we also did not find an acetylcholine releasing activity of ATP on the motor nerve endings in the frog's abdominal muscle.
    Original languageEnglish
    Pages (from-to)288-296
    Number of pages9
    JournalPflügers Archiv fuer die Gesamte Physiologie des Menschen und der Tiere
    Volume292
    Issue number4
    DOIs
    Publication statusPublished - 1966

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