Abstract
Background: Preterm infants with pre- or postnatal growth restriction may have an additional risk of adverse neurodevelopmental outcome. Whereas reduced cognitive ability and behavioral problems have consistently been associated with prematurity, a more comprehensive evaluation is necessary to identify those preterm infants who are at increased risk for difficulties in school performance. This study evaluated the association between extremely low birth weight (ELBW) and the need for special education and determined if there is an additional risk for the need for special education among small for gestational age (SGA) children. Methods: This is a single-center cohort study including singleton children born below 30 weeks' gestation between 1990 and 2011 and followed into 2019. ELBW + was defined as a birth weight below 1,000 g, which was compared to ELBW-. Within all ELBW+ children, SGA+ was defined as a birth weight <10th percentile according to Fenton, which was compared to SGA-. The dichotomous outcome measurement was the need for special education at 8 years of age or not, reflecting if the children required a special educational setting designed to accommodate educational, behavioral, and/or medical needs. Results: In total, 609 children were eligible for follow-up, of whom 390 (64%) children were assessed at 8 years. Of these, 56 (14%) children needed special education, most often determined by cognitive deficiency (43%), behavioral problems (29%), or both (16%). Among the 191 ELBW+ children, 35 (18%) attended special education, compared to 21 (11%) among ELBW- children (p-value 0.041). A decreasing risk for the need for special education was found from 25% in ELBW+/SGA+ children to 16% in ELBW+/SGA- children and 11% in ELBW-/SGA- children (p-value 0.025). Multivariable logistic regression showed an odds ratio of 2.88 (95% CI 1.20-6.78) for ELBW+/SGA+ children vs. ELBW-/SGA- children for the need for special education. Conclusions: This study showed that ELBW children are at increased risk for the need for special education compared to non-ELBW children. In addition, children that are both ELBW and SGA do have the highest risk for the need for special education. Classifying children as ELBW and SGA can be useful in follow-up for identifying preterm children with an additional risk for adverse long-term outcome.
| Original language | English |
|---|---|
| Article number | 719048 |
| Number of pages | 7 |
| Journal | Frontiers in Pediatrics |
| Volume | 9 |
| DOIs | |
| Publication status | Published - 20 Oct 2021 |
Funding
PB, AB, BV, and PA contributed to the conception of the study. PB, KP, IH, and BV organized the database. PB performed the statistical analysis and wrote the first draft of the manuscript. PA was responsible for the financial funding of the project and overall supervision. All authors contributed to the interpretation of the results, critically reviewed the manuscript, and approved the submitted version. The authors thank all neonatologists, physiotherapists, and psychologists of Máxima Medical Center (Veldhoven, Netherlands), in particular psychologist Titia Katgert, for their contribution in examining the children's neurodevelopment at (pre)school age. The authors thank Anne Verheijen, Guusje Thijssen, Anne van Och, René Blom, and Jasmijn van Erp for their help in creating the database for research use.
| Funders | Funder number |
|---|---|
| Máxima Medical Center | |
| Stichting Tiny & Anny van Doorne Fonds |
Keywords
- neurodevelopmental outcome
- small for gestational age
- special education
- very low birth weight
- very preterm children
Fingerprint
Dive into the research topics of 'The Need for Special Education Among ELBW and SGA Preterm Children: A Cohort Study'. Together they form a unique fingerprint.Research areas
-
Perinatal Medicine
van der Hout-van der Jagt, M. B. (Content manager) & Delvaux, E. (Content manager)
Impact: Research Topic/Theme (at group level)