The microprobe at the Eindhoven University of Technology

P.H.A. Mutsaers; G. Los; S.S. Klein; L.C. de Folter; M.J.A. de Voigt

doi:10.1016/0168-583X(90)90899-6

The microprobe at the Eindhoven University of Technology

P.H.A. Mutsaers
, G. Los
, S.S. Klein
, L.C. de Folter
, M.J.A. de Voigt

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

Abstract

The 3.5 MeV proton microbeam of the Eindhoven University of Technology is produced from an AVF cyclotron beam of 30 MeV maximum energy by a 1 × 1 mm² object diaphragm and a quadruplet lens system of high demagnification. A beam current of 150 nA was obtained in a spot of 60 × 40 μm² and a current of 2 nA in a spot of 10 × 10 μm². In the near future the minicyclotron ILEC will become operational. The beam specifications of this machine are an order of magnitude better for microprobe applications than those of the 30 MeV cyclotron. An important application of the present EUT microprobe is the detection of platinum in rat tumors treated with cisplatin. When higher currents are available in a small spot, sensitivity is limited by sample deterioration. Some methods to cope with those problems are discussed.

Original language	English
Pages (from-to)	557-560
Number of pages	4
Journal	Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
Volume	45
Issue number	1-4
DOIs	https://doi.org/10.1016/0168-583X(90)90899-6
Publication status	Published - 2 Jan 1990

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Cite this

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title = "The microprobe at the Eindhoven University of Technology",

abstract = "The 3.5 MeV proton microbeam of the Eindhoven University of Technology is produced from an AVF cyclotron beam of 30 MeV maximum energy by a 1 × 1 mm2 object diaphragm and a quadruplet lens system of high demagnification. A beam current of 150 nA was obtained in a spot of 60 × 40 μm2 and a current of 2 nA in a spot of 10 × 10 μm2. In the near future the minicyclotron ILEC will become operational. The beam specifications of this machine are an order of magnitude better for microprobe applications than those of the 30 MeV cyclotron. An important application of the present EUT microprobe is the detection of platinum in rat tumors treated with cisplatin. When higher currents are available in a small spot, sensitivity is limited by sample deterioration. Some methods to cope with those problems are discussed.",

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AU - Mutsaers, P.H.A.

AU - Los, G.

AU - Klein, S.S.

AU - de Folter, L.C.

AU - de Voigt, M.J.A.

PY - 1990/1/2

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AB - The 3.5 MeV proton microbeam of the Eindhoven University of Technology is produced from an AVF cyclotron beam of 30 MeV maximum energy by a 1 × 1 mm2 object diaphragm and a quadruplet lens system of high demagnification. A beam current of 150 nA was obtained in a spot of 60 × 40 μm2 and a current of 2 nA in a spot of 10 × 10 μm2. In the near future the minicyclotron ILEC will become operational. The beam specifications of this machine are an order of magnitude better for microprobe applications than those of the 30 MeV cyclotron. An important application of the present EUT microprobe is the detection of platinum in rat tumors treated with cisplatin. When higher currents are available in a small spot, sensitivity is limited by sample deterioration. Some methods to cope with those problems are discussed.

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JF - Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms

IS - 1-4

ER -

The microprobe at the Eindhoven University of Technology

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