The evolution of simulation techniques for dynamic bone tissue engineering in bioreactors

J.R. Vetsch, R. Müller, S. Hofmann

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)
538 Downloads (Pure)


Bone tissue engineering aims to overcome the drawbacks of current bone regeneration techniques in orthopaedics. Bioreactors are widely used in the field of bone tissue engineering, as they help support efficient nutrition of cultured cells with the possible combination of applying mechanical stimuli. Beneficial influencing parameters of in vitro cultures are difficult to find and are mostly determined by trial and error, which is associated with significant time and money spent. Mathematical simulations can support the finding of optimal parameters. Simulations have evolved over the last 20 years from simple analytical models to complex and detailed computational models. They allow researchers to simulate the mechanical as well as the biological environment experienced by cells seeded on scaffolds in a bioreactor. Based on the simulation results, it is possible to give recommendations about specific parameters for bone bioreactor cultures, such as scaffold geometries, scaffold mechanical properties, the level of applied mechanical loading or nutrient concentrations. This article reviews the evolution in simulating various aspects of dynamic bone culture in bioreactors and reveals future research directions.
Original languageEnglish
Pages (from-to)903-917
JournalJournal of Tissue Engineering and Regenerative Medicine
Issue number8
Publication statusPublished - 2015


Dive into the research topics of 'The evolution of simulation techniques for dynamic bone tissue engineering in bioreactors'. Together they form a unique fingerprint.

Cite this