TY - JOUR
T1 - The crux of maximum hyperemia
T2 - the last remaining barrier for routine use of fractional flow reserve
AU - Pijls, Nico H.J.
AU - Tonino, Pim A.L.
PY - 2011/10/1
Y1 - 2011/10/1
N2 - In the decision-making process of revascularization of coronary artery stenoses by percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery (CABG), the presence and extent of reversible ischemia associated with such particular stenoses is of paramount importance (1, 2, 3). A stenosis associated with reversible ischemia (also called functionally significant or hemodynamically significant stenosis) causes symptoms of angina pectoris and has a negative influence on outcome (1, 2). Therefore, the general feeling is that such lesions should be revascularized if technically feasible. On the contrary, functionally nonsignificant stenoses do not cause symptoms by definition and have an excellent outcome with medical therapy (3, 4, 5). Therefore, revascularization of such lesions is generally not indicated.
AB - In the decision-making process of revascularization of coronary artery stenoses by percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery (CABG), the presence and extent of reversible ischemia associated with such particular stenoses is of paramount importance (1, 2, 3). A stenosis associated with reversible ischemia (also called functionally significant or hemodynamically significant stenosis) causes symptoms of angina pectoris and has a negative influence on outcome (1, 2). Therefore, the general feeling is that such lesions should be revascularized if technically feasible. On the contrary, functionally nonsignificant stenoses do not cause symptoms by definition and have an excellent outcome with medical therapy (3, 4, 5). Therefore, revascularization of such lesions is generally not indicated.
KW - adenosine
KW - fractional flow reserve
KW - maximum hyperemia
KW - regadenoson
UR - http://www.scopus.com/inward/record.url?scp=80054970214&partnerID=8YFLogxK
U2 - 10.1016/j.jcin.2011.08.007
DO - 10.1016/j.jcin.2011.08.007
M3 - Comment/Letter to the editor
C2 - 22017934
AN - SCOPUS:80054970214
VL - 4
SP - 1093
EP - 1095
JO - JACC: Cardiovascular Interventions
JF - JACC: Cardiovascular Interventions
SN - 1936-8798
IS - 10
ER -