The convenient synthesis of hydrogen-bonded ureidopyrimidinones

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Blocked isocytosine isocyanates are conveniently obtained by the reaction of 1,1'-carbonyldiimidazole (CDI) with isocytosines. The resulting precursors for quadruple hydrogen-bonded structures can be isolated and stored for further use. Reaction with either aliph. or arom. amines gives the corresponding mono-, bi-, or trifunctional ureidopyrimidinone derivs. in good to excellent isolated yields.
Original languageEnglish
Pages (from-to)2553-2555
Number of pages3
JournalEuropean Journal of Organic Chemistry
Issue number12
Publication statusPublished - 2004


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