The binding of CNA35 contrast agents to collagen fibrils

H.M.H.F. Sanders; M. Iafisco; E.M. Pouget; P.H.H. Bomans; F. Nudelman; G. Falini; G. With, de; M. Merkx; G.J. Strijkers; K. Nicolaij; N.A.J.M. Sommerdijk

doi:10.1039/c0cc02901g

The binding of CNA35 contrast agents to collagen fibrils

H.M.H.F. Sanders, M. Iafisco, E.M. Pouget, P.H.H. Bomans, F. Nudelman, G. Falini, G. With, de, M. Merkx, G.J. Strijkers, K. Nicolaij, N.A.J.M. Sommerdijk

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Abstract

CryoTEM demonstrates that a CNA35-bearing liposomal MRI contrast agent selectively binds to poorly assembled collagen type I as opposed to well-assembled collagen fibrils, whereas monomeric CNA35 binds to all forms of collagen. It is shown that upon conjugation to liposomes and micelles CNA35 loses its ability to dissociate ordered collagen fibrils and thereby to create its own binding sites.

Original language	English
Pages (from-to)	1503-1505
Number of pages	3
Journal	Chemical Communications, ChemComm
Volume	47
Issue number	5
DOIs	https://doi.org/10.1039/c0cc02901g
Publication status	Published - 2011

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10.1039/c0cc02901g

Center for Multiscale Electron Microscopy (CMEM)
Friedrich, H. (Manager), Joosten, R. (Education/research officer), Schmit, P. (Education/research officer), Schreur - Piet, I. (Other) & Spoelstra, A. (Education/research officer)
Physical Chemistry
Facility/equipment: Research lab

Cite this

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title = "The binding of CNA35 contrast agents to collagen fibrils",

abstract = "CryoTEM demonstrates that a CNA35-bearing liposomal MRI contrast agent selectively binds to poorly assembled collagen type I as opposed to well-assembled collagen fibrils, whereas monomeric CNA35 binds to all forms of collagen. It is shown that upon conjugation to liposomes and micelles CNA35 loses its ability to dissociate ordered collagen fibrils and thereby to create its own binding sites.",

author = "H.M.H.F. Sanders and M. Iafisco and E.M. Pouget and P.H.H. Bomans and F. Nudelman and G. Falini and {With, de}, G. and M. Merkx and G.J. Strijkers and K. Nicolaij and N.A.J.M. Sommerdijk",

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AU - Sanders, H.M.H.F.

AU - Iafisco, M.

AU - Pouget, E.M.

AU - Bomans, P.H.H.

AU - Nudelman, F.

AU - Falini, G.

AU - With, de, G.

AU - Merkx, M.

AU - Strijkers, G.J.

AU - Nicolaij, K.

AU - Sommerdijk, N.A.J.M.

PY - 2011

Y1 - 2011

N2 - CryoTEM demonstrates that a CNA35-bearing liposomal MRI contrast agent selectively binds to poorly assembled collagen type I as opposed to well-assembled collagen fibrils, whereas monomeric CNA35 binds to all forms of collagen. It is shown that upon conjugation to liposomes and micelles CNA35 loses its ability to dissociate ordered collagen fibrils and thereby to create its own binding sites.

AB - CryoTEM demonstrates that a CNA35-bearing liposomal MRI contrast agent selectively binds to poorly assembled collagen type I as opposed to well-assembled collagen fibrils, whereas monomeric CNA35 binds to all forms of collagen. It is shown that upon conjugation to liposomes and micelles CNA35 loses its ability to dissociate ordered collagen fibrils and thereby to create its own binding sites.

U2 - 10.1039/c0cc02901g

DO - 10.1039/c0cc02901g

M3 - Article

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VL - 47

SP - 1503

EP - 1505

JO - Chemical Communications, ChemComm

JF - Chemical Communications, ChemComm

IS - 5

ER -

The binding of CNA35 contrast agents to collagen fibrils

Abstract

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