The antiangiogenic properties of bactericidal/permeability-increasing protein (BPI).

D.W.J. Schaft, van der, J. Wagstaff, K.H. Mayo, A.W. Griffioen

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)


Inhibition of angiogenesis is regarded as a promising tool in the treatment of diseases such as cancer, arthritis and atherosclerosis. This fact has led to the search for novel endogenous or synthetic angiogenesis inhibitors. Recently, antiangiogenic properties were ascribed to an endogenous molecule that until only recently was known for its anti-bacterial effects. This molecule, bactericidal/permeability-increasing protein (BPI), that was discovered as a bacterial permeabilizing and lipopolysaccharide-neutralizing protein, was found to inhibit angiogenesis by specific induction of apoptosis in endothelial cells. This paper gives a short introduction on angiogenesis and reviews the current knowledge on BPI as an angiogenesis inhibitor. In addition, the issue of commonality between antibacterial and anti-angiogenic functions will be addressed.
Original languageEnglish
Pages (from-to)19-27
JournalAnnals of Medicine
Issue number1
Publication statusPublished - 2002


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