The accelerated preparation of 1,4-dihydropyridines using microflow reactors

P. Tambarussi Baraldi; T. Noel; Q. Wang; V. Hessel

doi:10.1016/j.tetlet.2014.02.041

The accelerated preparation of 1,4-dihydropyridines using microflow reactors

P. Tambarussi Baraldi, T. Noel, Q. Wang, V. Hessel

Micro Flow Chemistry and Synthetic Methodology

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Abstract

The synthesis of 1,4-dihydropyridines was performed in a continuous-flow microreactor. Elevated temperatures accelerated the reaction rate significantly allowing the reaction to be finished in minutes (6–11 min). Different 1,4-dihydropyridines were prepared in good to excellent isolated yields (45–88% yield). The method was amenable to the preparation of daropidine, a calcium channel blocker which is currently in clinical phase 3 trials

Original language	English
Pages (from-to)	2090-2092
Number of pages	3
Journal	Tetrahedron Letters
Volume	55
Issue number	13
DOIs	https://doi.org/10.1016/j.tetlet.2014.02.041
Publication status	Published - 2014

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10.1016/j.tetlet.2014.02.041

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title = "The accelerated preparation of 1,4-dihydropyridines using microflow reactors",

abstract = "The synthesis of 1,4-dihydropyridines was performed in a continuous-flow microreactor. Elevated temperatures accelerated the reaction rate significantly allowing the reaction to be finished in minutes (6–11 min). Different 1,4-dihydropyridines were prepared in good to excellent isolated yields (45–88\% yield). The method was amenable to the preparation of daropidine, a calcium channel blocker which is currently in clinical phase 3 trials",

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T1 - The accelerated preparation of 1,4-dihydropyridines using microflow reactors

AU - Tambarussi Baraldi, P.

AU - Noel, T.

AU - Wang, Q.

AU - Hessel, V.

PY - 2014

Y1 - 2014

N2 - The synthesis of 1,4-dihydropyridines was performed in a continuous-flow microreactor. Elevated temperatures accelerated the reaction rate significantly allowing the reaction to be finished in minutes (6–11 min). Different 1,4-dihydropyridines were prepared in good to excellent isolated yields (45–88% yield). The method was amenable to the preparation of daropidine, a calcium channel blocker which is currently in clinical phase 3 trials

AB - The synthesis of 1,4-dihydropyridines was performed in a continuous-flow microreactor. Elevated temperatures accelerated the reaction rate significantly allowing the reaction to be finished in minutes (6–11 min). Different 1,4-dihydropyridines were prepared in good to excellent isolated yields (45–88% yield). The method was amenable to the preparation of daropidine, a calcium channel blocker which is currently in clinical phase 3 trials

U2 - 10.1016/j.tetlet.2014.02.041

DO - 10.1016/j.tetlet.2014.02.041

M3 - Article

SN - 0040-4039

VL - 55

SP - 2090

EP - 2092

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 13

ER -

The accelerated preparation of 1,4-dihydropyridines using microflow reactors

Abstract

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