The accelerated preparation of 1,4-dihydropyridines using microflow reactors

P. Tambarussi Baraldi, T. Noel, Q. Wang, V. Hessel

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)
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Abstract

The synthesis of 1,4-dihydropyridines was performed in a continuous-flow microreactor. Elevated temperatures accelerated the reaction rate significantly allowing the reaction to be finished in minutes (6–11 min). Different 1,4-dihydropyridines were prepared in good to excellent isolated yields (45–88% yield). The method was amenable to the preparation of daropidine, a calcium channel blocker which is currently in clinical phase 3 trials
Original languageEnglish
Pages (from-to)2090-2092
Number of pages3
JournalTetrahedron Letters
Volume55
Issue number13
DOIs
Publication statusPublished - 2014

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