The 2-(acetoxymethyl)benzoyl (AMB) group as a new base-protecting group, designed for the protection of (phosphate) modified oligonucleotides.

W.H.A. Kuijpers, J. Huskens, C.A.A. Boeckel, van

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Abstract

The 2-(acetoxymethyl)benzoyl (AMB) group is a new base-protecting group that facilitates the synthesis of labile, modified nucleotides, since it can be rapidly cleaved under mild basic conditions. The 2-(acetoxymethyl)benzoyl (AMB) group is a new base-protecting group that facilitates the synthesis of labile, modified nucleotides, since it can be rapidly cleaved under mild basic conditions: 0.05 M K2CO3/MeOH (r.t.) 30–60 min.; 32% aq. ammonia (r.t.) 1–2 hr.
Original languageEnglish
Pages (from-to)6729-6732
JournalTetrahedron Letters
Volume31
Issue number46
DOIs
Publication statusPublished - 1990

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