Tethered particle motion (TPM) characterizes binding types for lab-on-a-chip biosensing

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Abstract

We present a study on the application of tethered particle motion (TPM) for biosensing. Specifically, we investigate the dynamics of surface bound particles using TPM. In a model system, we demonstrate that particle binding to a sensor surface can be controlled via single tethers and via multiple tethers, and that the binding types can be quantified with TPM in an optical biosensing system.

Original languageEnglish
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages2303-2305
Number of pages3
ISBN (Electronic)9780979806476
Publication statusPublished - 1 Jan 2014
Event18th Intermational Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014) - San Antonio, United States
Duration: 26 Oct 201430 Oct 2014
Conference number: 18
http://www.microtasconferences.org/microtas2014/

Conference

Conference18th Intermational Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014)
Abbreviated titleMicroTAS 2014
CountryUnited States
CitySan Antonio
Period26/10/1430/10/14
Internet address

Keywords

  • Biosensing
  • Bond discrimination
  • Bond dynamics
  • Particles
  • Tethered particle motion

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  • Cite this

    Visser, E. W. A., IJzendoorn, van, L. J., & Prins, M. W. J. (2014). Tethered particle motion (TPM) characterizes binding types for lab-on-a-chip biosensing. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 2303-2305). Chemical and Biological Microsystems Society.