Tethered particle motion (TPM) characterizes binding types for lab-on-a-chip biosensing

E.W.A. Visser; L.J. IJzendoorn, van; M.W.J. Prins

Tethered particle motion (TPM) characterizes binding types for lab-on-a-chip biosensing

E.W.A. Visser, L.J. IJzendoorn, van, M.W.J. Prins

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

We present a study on the application of tethered particle motion (TPM) for biosensing. Specifically, we investigate the dynamics of surface bound particles using TPM. In a model system, we demonstrate that particle binding to a sensor surface can be controlled via single tethers and via multiple tethers, and that the binding types can be quantified with TPM in an optical biosensing system.

Original language	English
Title of host publication	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Publisher	Chemical and Biological Microsystems Society
Pages	2303-2305
Number of pages	3
ISBN (Electronic)	9780979806476
Publication status	Published - 1 Jan 2014
Event	18th Intermational Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States Duration: 26 Oct 2014 → 30 Oct 2014 Conference number: 18 http://www.microtasconferences.org/microtas2014/

Conference

Conference	18th Intermational Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Abbreviated title	MicroTAS 2014
Country/Territory	United States
City	San Antonio
Period	26/10/14 → 30/10/14
Internet address	http://www.microtasconferences.org/microtas2014/

Keywords

Biosensing
Bond discrimination
Bond dynamics
Particles
Tethered particle motion

Cite this

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title = "Tethered particle motion (TPM) characterizes binding types for lab-on-a-chip biosensing",

abstract = "We present a study on the application of tethered particle motion (TPM) for biosensing. Specifically, we investigate the dynamics of surface bound particles using TPM. In a model system, we demonstrate that particle binding to a sensor surface can be controlled via single tethers and via multiple tethers, and that the binding types can be quantified with TPM in an optical biosensing system.",

keywords = "Biosensing, Bond discrimination, Bond dynamics, Particles, Tethered particle motion",

author = "E.W.A. Visser and {IJzendoorn, van}, L.J. and M.W.J. Prins",

year = "2014",

month = jan,

day = "1",

language = "English",

pages = "2303--2305",

booktitle = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",

publisher = "Chemical and Biological Microsystems Society",

note = "18th Intermational Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, MicroTAS 2014 ; Conference date: 26-10-2014 Through 30-10-2014",

url = "http://www.microtasconferences.org/microtas2014/",

}

Visser, EWA, IJzendoorn, van, LJ & Prins, MWJ 2014, Tethered particle motion (TPM) characterizes binding types for lab-on-a-chip biosensing. in 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, pp. 2303-2305, 18th Intermational Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, San Antonio, Texas, United States, 26/10/14.

Tethered particle motion (TPM) characterizes binding types for lab-on-a-chip biosensing. / Visser, E.W.A.; IJzendoorn, van, L.J.; Prins, M.W.J.

18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. p. 2303-2305.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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AU - IJzendoorn, van, L.J.

AU - Prins, M.W.J.

N1 - Conference code: 18

PY - 2014/1/1

Y1 - 2014/1/1

N2 - We present a study on the application of tethered particle motion (TPM) for biosensing. Specifically, we investigate the dynamics of surface bound particles using TPM. In a model system, we demonstrate that particle binding to a sensor surface can be controlled via single tethers and via multiple tethers, and that the binding types can be quantified with TPM in an optical biosensing system.

AB - We present a study on the application of tethered particle motion (TPM) for biosensing. Specifically, we investigate the dynamics of surface bound particles using TPM. In a model system, we demonstrate that particle binding to a sensor surface can be controlled via single tethers and via multiple tethers, and that the binding types can be quantified with TPM in an optical biosensing system.

KW - Biosensing

KW - Bond discrimination

KW - Bond dynamics

KW - Particles

KW - Tethered particle motion

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M3 - Conference contribution

SP - 2303

EP - 2305

BT - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

PB - Chemical and Biological Microsystems Society

T2 - 18th Intermational Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Y2 - 26 October 2014 through 30 October 2014

ER -

Tethered particle motion (TPM) characterizes binding types for lab-on-a-chip biosensing

Abstract

Conference

Keywords

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