TCP-HA granules and impacted morselized cancellous bone graft mixes for acetabular reconstruction with the bone impaction grafting technique : a loaded and critical sized defect model in the goat

J.J.C. Arts, J.W.M. Gardeniers, M.L.M. Welten, N. Verdonschot, B.W. Schreurs, P. Buma

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With the bone impaction grafting technique, a 50/50 volume mix of morselized cancellous bone (MCB) with TCP-HA granules was used to reconstruct a critical sized acetabular defect in the goat. The biological activity of the MCB/TCP-HA mix was assessed after 15 weeks. Defects filled with 100% MCB, currently the gold standard for this technique, were used as controls. In the 100% MCB defects, a new trabecular bone structure was found in which scarce incorporated remnants of the original graft material were present. In the MCB/TCP-HA defects, MCB was also resorbed or incorporated into new bone. Deep in the MCB-TCP-HA defects, large TCP-HA granules were generally totally osseous-integrated with new bone. Superficially, more fragmented TCP-HA granules of various sizes were present in the medullar tissue or in the interface with the cement layer. Here, the crushed TCP-HA granules were generally surrounded by osteoclasts and giant cells. The soft tissue interface between the reconstruction and cement did not differ between both groups. In conclusion, from a biological point of view, this short-term follow-up study suggests that TCP-HA granules can be safely used in a mix with MCB as bone graft extender in acetabular revision surgery with the bone impaction grafting technique.

Original languageEnglish
Pages (from-to)869-872
Number of pages4
JournalKey Engineering Materials
Publication statusPublished - 1 Dec 2005
Externally publishedYes



  • Animal model
  • Bone conduction
  • Bone graft substitute
  • Hydroxyapatite
  • Reconstructive surgery
  • Tricalcium phosphate

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