System identification to analyse changed kinetics of SERCA in intact rat heart

Natal A.W. van Riel; Tamas Ivanics; Laszlo Ligeti; Ger J. van der Vusse

doi:10.1016/S1474-6670(17)33486-9

System identification to analyse changed kinetics of SERCA in intact rat heart

Natal A.W. van Riel (Corresponding author), Tamas Ivanics, Laszlo Ligeti, Ger J. van der Vusse

Research output: Contribution to journal › Conference article › peer-review

3 Citations (Scopus)

Abstract

A mechanistic-based model has been derived of calcium handling in the intact heart. This model incorporates the quantitatively most important processes involved in beat-to-beat calcium homeostasis. Based on a priori physiological information the model has been reduced to yield (kinetic) parameters that could be estimated using time-series data of the free calcium concentration in the sarcoplasma. Observations of the dynamics of the overall system were translated into the underlying mechanisms. Experiments in which the most important calcium extrusion pump (Sarcoplasmic Reticulum Ca ²⁺ -ATPase, SERCA) was disturbed have been successfully analysed and interpreted using model and identification.

Original language	English
Pages (from-to)	125-128
Number of pages	4
Journal	IFAC Proceedings Volumes
Volume	36
Issue number	15
DOIs	https://doi.org/10.1016/S1474-6670(17)33486-9
Publication status	Published - 1 Jan 2003
Event	5th IFAC Symposium on Modelling and Control in Biomedical Systems 2003 - Melbourne, Australia Duration: 21 Aug 2003 → 23 Aug 2003

Keywords

Dynamic models
Identifiability
Least-squares identification
Model reduction
Parameter estimation
Physiological models

Access to Document

10.1016/S1474-6670(17)33486-9

Cite this

@article{8697bef50efd44729b6e642a058eb762,

title = "System identification to analyse changed kinetics of SERCA in intact rat heart",

abstract = " A mechanistic-based model has been derived of calcium handling in the intact heart. This model incorporates the quantitatively most important processes involved in beat-to-beat calcium homeostasis. Based on a priori physiological information the model has been reduced to yield (kinetic) parameters that could be estimated using time-series data of the free calcium concentration in the sarcoplasma. Observations of the dynamics of the overall system were translated into the underlying mechanisms. Experiments in which the most important calcium extrusion pump (Sarcoplasmic Reticulum Ca 2+ -ATPase, SERCA) was disturbed have been successfully analysed and interpreted using model and identification. ",

keywords = "Dynamic models, Identifiability, Least-squares identification, Model reduction, Parameter estimation, Physiological models",

author = "{van Riel}, {Natal A.W.} and Tamas Ivanics and Laszlo Ligeti and {van der Vusse}, {Ger J.}",

year = "2003",

month = jan,

day = "1",

doi = "10.1016/S1474-6670(17)33486-9",

language = "English",

volume = "36",

pages = "125--128",

journal = "IFAC Proceedings Volumes",

issn = "1474-6670",

publisher = "Elsevier",

number = "15",

note = "5th IFAC Symposium on Modelling and Control in Biomedical Systems 2003 ; Conference date: 21-08-2003 Through 23-08-2003",

}

TY - JOUR

T1 - System identification to analyse changed kinetics of SERCA in intact rat heart

AU - van Riel, Natal A.W.

AU - Ivanics, Tamas

AU - Ligeti, Laszlo

AU - van der Vusse, Ger J.

PY - 2003/1/1

Y1 - 2003/1/1

N2 - A mechanistic-based model has been derived of calcium handling in the intact heart. This model incorporates the quantitatively most important processes involved in beat-to-beat calcium homeostasis. Based on a priori physiological information the model has been reduced to yield (kinetic) parameters that could be estimated using time-series data of the free calcium concentration in the sarcoplasma. Observations of the dynamics of the overall system were translated into the underlying mechanisms. Experiments in which the most important calcium extrusion pump (Sarcoplasmic Reticulum Ca 2+ -ATPase, SERCA) was disturbed have been successfully analysed and interpreted using model and identification.

AB - A mechanistic-based model has been derived of calcium handling in the intact heart. This model incorporates the quantitatively most important processes involved in beat-to-beat calcium homeostasis. Based on a priori physiological information the model has been reduced to yield (kinetic) parameters that could be estimated using time-series data of the free calcium concentration in the sarcoplasma. Observations of the dynamics of the overall system were translated into the underlying mechanisms. Experiments in which the most important calcium extrusion pump (Sarcoplasmic Reticulum Ca 2+ -ATPase, SERCA) was disturbed have been successfully analysed and interpreted using model and identification.

KW - Dynamic models

KW - Identifiability

KW - Least-squares identification

KW - Model reduction

KW - Parameter estimation

KW - Physiological models

UR - http://www.scopus.com/inward/record.url?scp=11144333832&partnerID=8YFLogxK

U2 - 10.1016/S1474-6670(17)33486-9

DO - 10.1016/S1474-6670(17)33486-9

M3 - Conference article

AN - SCOPUS:11144333832

SN - 1474-6670

VL - 36

SP - 125

EP - 128

JO - IFAC Proceedings Volumes

JF - IFAC Proceedings Volumes

IS - 15

T2 - 5th IFAC Symposium on Modelling and Control in Biomedical Systems 2003

Y2 - 21 August 2003 through 23 August 2003

ER -

System identification to analyse changed kinetics of SERCA in intact rat heart

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this