Synthetic elastography from B-mode ultrasound through deep learning

R.R. Wildeboer, R.J.G. van Sloun, Christophe K. Mannaerts, G. Salomon, H. Wijkstra, M. Mischi

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Tissue elasticity can be locally estimated using shear-wave elastography (SWE), an advanced technique that measures the speed of laterally-traveling shear waves induced by a sequence of acoustic radiation force "push" pulses. However, SWE is not available on all ultrasound machines due to e.g. power, equipment, and procedural requirements; in particular, wireless devices would face challenges delivering the required power. Here, we propose a fully-convolutional deep neural network for the synthesis of an SWE image given the corresponding B-mode (side-by-side-view) image. Fifty patients diagnosed with prostate cancer underwent a transrectal SWE examination with SWE imaging regions chosen such that they covered the entire or parts of the prostate. The network was trained with the images of 40 patients and subsequently tested using 30 image planes from the remaining 10 patients. The neural network was able to accurately map the B-mode images to sSWE images with a pixel-wise mean absolute error of 4.8 kPa in terms of Young's modulus. Qualitatively, tumour sites characterized by high stiffness were mostly preserved (as validated by histopathology). Despite the need for further validation, our results already suggest that deep learning is a viable way to retrieve elasticity values from conventional B-mode images and can potentially provide valuable information for cancer diagnosis using devices on which no SWE imaging is available.

Original languageEnglish
Title of host publication2019 IEEE International Ultrasonics Symposium, IUS 2019
Place of PublicationPiscataway
PublisherIEEE Computer Society
Pages108-110
Number of pages3
ISBN (Electronic)9781728145969
DOIs
Publication statusPublished - Oct 2019
Event2019 IEEE International Ultrasonics Symposium, IUS 2019 - Glasgow, United Kingdom
Duration: 6 Oct 20199 Oct 2019

Conference

Conference2019 IEEE International Ultrasonics Symposium, IUS 2019
CountryUnited Kingdom
CityGlasgow
Period6/10/199/10/19

Keywords

  • B-mode Ultrasound
  • Convolutional Neural Networks
  • Deep Learning
  • Shear-Wave Elastography

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