Synthesis tool for separation processes in the pharmaceutical industry

A.I.C. Morao; E. Zondervan; G. Krooshof; R. Geertman; A.B. Haan, de

doi:10.1016/B978-0-444-53711-9.50056-0

Synthesis tool for separation processes in the pharmaceutical industry

A.I.C. Morao, E. Zondervan, G. Krooshof, R. Geertman, A.B. Haan, de

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

A synthesis tool to select promising separation routes to purify active pharmaceutical ingredients is introduced in this paper. It combines heuristics with flowsheet simulations to systematically generate and compare alternatives. The application of this framework to the purification of progesterone led to new insights that must be confirmed by experiments

Original language	English
Pages (from-to)	276-280
Number of pages	5
Journal	Computer Aided Chemical Engineering
Volume	29
DOIs	https://doi.org/10.1016/B978-0-444-53711-9.50056-0
Publication status	Published - 2011

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title = "Synthesis tool for separation processes in the pharmaceutical industry",

abstract = "A synthesis tool to select promising separation routes to purify active pharmaceutical ingredients is introduced in this paper. It combines heuristics with flowsheet simulations to systematically generate and compare alternatives. The application of this framework to the purification of progesterone led to new insights that must be confirmed by experiments",

author = "A.I.C. Morao and E. Zondervan and G. Krooshof and R. Geertman and \{Haan, de\}, A.B.",

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AU - Morao, A.I.C.

AU - Zondervan, E.

AU - Krooshof, G.

AU - Geertman, R.

AU - Haan, de, A.B.

PY - 2011

Y1 - 2011

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AB - A synthesis tool to select promising separation routes to purify active pharmaceutical ingredients is introduced in this paper. It combines heuristics with flowsheet simulations to systematically generate and compare alternatives. The application of this framework to the purification of progesterone led to new insights that must be confirmed by experiments

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DO - 10.1016/B978-0-444-53711-9.50056-0

M3 - Article

SN - 1570-7946

VL - 29

SP - 276

EP - 280

JO - Computer Aided Chemical Engineering

JF - Computer Aided Chemical Engineering

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Synthesis tool for separation processes in the pharmaceutical industry

Abstract

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