Synthesis tool for separation processes in the pharmaceutical industry

A.I.C. Morao, E. Zondervan, G. Krooshof, R. Geertman, A.B. Haan, de

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    Abstract

    A synthesis tool to select promising separation routes to purify active pharmaceutical ingredients is introduced in this paper. It combines heuristics with flowsheet simulations to systematically generate and compare alternatives. The application of this framework to the purification of progesterone led to new insights that must be confirmed by experiments
    Original languageEnglish
    Pages (from-to)276-280
    Number of pages5
    JournalComputer Aided Chemical Engineering
    Volume29
    DOIs
    Publication statusPublished - 2011

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