Synthesis of the Rheb and K-Ras4B GTPases

Y.X. Chen, S. Koch, K. Uhlenbrock, K. Weise, D. Das, L. Gremer, L. Brunsveld, A. Wittinghofer, R. Winter, G. Triola, H. Waldmann

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Farnesylated and carboxymethylated Rheb (see picture) and K-Ras4B GTPases were synthesized in useful amounts by a combination of expressed protein ligation and solid-phase lipopeptide synthesis. The functionality of the proteins was proven by biochemical, biophysical, and cell-based investigations.
Original languageEnglish
Pages (from-to)6090-6095
Number of pages6
JournalAngewandte Chemie - International Edition
Volume49
Issue number35
DOIs
Publication statusPublished - 2010

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