Synthesis of the Rheb and K-Ras4B GTPases

Y.X. Chen, S. Koch, K. Uhlenbrock, K. Weise, D. Das, L. Gremer, L. Brunsveld, A. Wittinghofer, R. Winter, G. Triola, H. Waldmann

Research output: Contribution to journalArticleAcademicpeer-review

66 Citations (Scopus)
1 Downloads (Pure)


Farnesylated and carboxymethylated Rheb (see picture) and K-Ras4B GTPases were synthesized in useful amounts by a combination of expressed protein ligation and solid-phase lipopeptide synthesis. The functionality of the proteins was proven by biochemical, biophysical, and cell-based investigations.
Original languageEnglish
Pages (from-to)6090-6095
Number of pages6
JournalAngewandte Chemie - International Edition
Issue number35
Publication statusPublished - 2010


Dive into the research topics of 'Synthesis of the Rheb and K-Ras4B GTPases'. Together they form a unique fingerprint.

Cite this