Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform

Anita Gianella, Aneta J. Mieszawska, Freek J.M. Hoeben, Henk M. Janssen, Peter A. Jarzyna, David P. Cormode, Kevin D. Costa, Satish Rao, Omid C. Farokhzad, Robert Langer, Zahi A. Fayad, Willem J.M. Mulder (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Abstract

We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles.

Original languageEnglish
Pages (from-to)9392-9394
Number of pages3
JournalChemical Communications
Volume49
Issue number82
DOIs
Publication statusPublished - 21 Oct 2013

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