Abstract
Chemical protein synthesis allows the generation of milligram quantities of correctly folded and previously inaccessible tyrosine-phosphorylated estrogen receptor a (ERa) and ß (ERß) ligand binding domains. By using this synthetic strategy, the crystal structure of a post-translationally modified nuclear receptor (pY488 ERß) could be obtained for the first time
Original language | English |
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Pages (from-to) | 2251-2254 |
Journal | ChemBioChem |
Volume | 11 |
Issue number | 16 |
DOIs | |
Publication status | Published - 2010 |