Synthesis and controlled polymerisation of a novel gramicidin S Analogue

L. Ayres, G.M. Grotenbreg, G.A. van der Marel, H.S. Overkleeft, M. Overhand, J.C.M. Hest, van

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)

Abstract

The controlled polymerisation of a bulky, peptide-based monomer was investigated. The cyclic β-sheet forming decapeptide gramicidin S was modified with a methacrylate handle and subsequently polymerised via atom transfer radical polymerisation (ATRP), to yield a well-defined gramicidin-S-containing polymer. The secondary structure of the peptide moiety was retained within the resulting polymer, as indicated by IR spectroscopy. This is the first example of the use of ATRP to create a synthetic polymer with a cyclic peptide as a side chain.

Original languageEnglish
Pages (from-to)1336-1340
Number of pages5
JournalMacromolecular Rapid Communications
Volume26
Issue number16
DOIs
Publication statusPublished - 19 Aug 2005
Externally publishedYes

Keywords

  • Atom transfer radical polymerisation (ATRP)
  • Beta-sheets
  • Gramicidin S
  • Peptides
  • Side-chain polymers

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