Synthesis and characterization of polyethyl cyanoacrylate nanoparticles loaded with capreomycin sulfate

L. Zhaparova, Y.M. Tazhbayev, M.Zh. Burkeev, A.T. Kazhmuratova, T.S. Zhumagaliyeva, S.I. Ali, A.M. Herk, van

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    2 Citations (Scopus)
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    Abstract

    Some aspects of the synthesis and characterization of polyethyl cyanoacrylate nanoparticles loaded with the antituberculosis drug capreomycin sulfate are considered in this work. Polyethyl cyanoacrylate nanoparticles containing capreomycin sulfate have been synthesized using anionic polymerization in emulsion. Optimum conditions of immobilization of the drug into the polymeric matrix have been found. It was determined that to increase the loading efficiency of the drug, it has to be added into the reaction medium after polymerization has started.
    Original languageEnglish
    Pages (from-to)6-9
    Number of pages4
    JournalPharmaceutical Chemistry Journal
    Volume46
    Issue number1
    DOIs
    Publication statusPublished - 2012

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