Synthesis and characterization of polyethyl cyanoacrylate nanoparticles loaded with capreomycin sulfate

L. Zhaparova, Y.M. Tazhbayev, M.Zh. Burkeev, A.T. Kazhmuratova, T.S. Zhumagaliyeva, S.I. Ali, A.M. Herk, van

    Research output: Contribution to journalArticleAcademicpeer-review

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    Abstract

    Some aspects of the synthesis and characterization of polyethyl cyanoacrylate nanoparticles loaded with the antituberculosis drug capreomycin sulfate are considered in this work. Polyethyl cyanoacrylate nanoparticles containing capreomycin sulfate have been synthesized using anionic polymerization in emulsion. Optimum conditions of immobilization of the drug into the polymeric matrix have been found. It was determined that to increase the loading efficiency of the drug, it has to be added into the reaction medium after polymerization has started.
    Original languageEnglish
    Pages (from-to)6-9
    Number of pages4
    JournalPharmaceutical Chemistry Journal
    Volume46
    Issue number1
    DOIs
    Publication statusPublished - 2012

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    Capreomycin
    Nanoparticles
    Polymerization
    Pharmaceutical Preparations
    Emulsions
    Immobilization
    poly(ethylcyanoacrylate)

    Cite this

    Zhaparova, L., Tazhbayev, Y. M., Burkeev, M. Z., Kazhmuratova, A. T., Zhumagaliyeva, T. S., Ali, S. I., & Herk, van, A. M. (2012). Synthesis and characterization of polyethyl cyanoacrylate nanoparticles loaded with capreomycin sulfate. Pharmaceutical Chemistry Journal, 46(1), 6-9. https://doi.org/10.1007/s11094-012-0724-1
    Zhaparova, L. ; Tazhbayev, Y.M. ; Burkeev, M.Zh. ; Kazhmuratova, A.T. ; Zhumagaliyeva, T.S. ; Ali, S.I. ; Herk, van, A.M. / Synthesis and characterization of polyethyl cyanoacrylate nanoparticles loaded with capreomycin sulfate. In: Pharmaceutical Chemistry Journal. 2012 ; Vol. 46, No. 1. pp. 6-9.
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    abstract = "Some aspects of the synthesis and characterization of polyethyl cyanoacrylate nanoparticles loaded with the antituberculosis drug capreomycin sulfate are considered in this work. Polyethyl cyanoacrylate nanoparticles containing capreomycin sulfate have been synthesized using anionic polymerization in emulsion. Optimum conditions of immobilization of the drug into the polymeric matrix have been found. It was determined that to increase the loading efficiency of the drug, it has to be added into the reaction medium after polymerization has started.",
    author = "L. Zhaparova and Y.M. Tazhbayev and M.Zh. Burkeev and A.T. Kazhmuratova and T.S. Zhumagaliyeva and S.I. Ali and {Herk, van}, A.M.",
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    Zhaparova, L, Tazhbayev, YM, Burkeev, MZ, Kazhmuratova, AT, Zhumagaliyeva, TS, Ali, SI & Herk, van, AM 2012, 'Synthesis and characterization of polyethyl cyanoacrylate nanoparticles loaded with capreomycin sulfate', Pharmaceutical Chemistry Journal, vol. 46, no. 1, pp. 6-9. https://doi.org/10.1007/s11094-012-0724-1

    Synthesis and characterization of polyethyl cyanoacrylate nanoparticles loaded with capreomycin sulfate. / Zhaparova, L.; Tazhbayev, Y.M.; Burkeev, M.Zh.; Kazhmuratova, A.T.; Zhumagaliyeva, T.S.; Ali, S.I.; Herk, van, A.M.

    In: Pharmaceutical Chemistry Journal, Vol. 46, No. 1, 2012, p. 6-9.

    Research output: Contribution to journalArticleAcademicpeer-review

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    AU - Zhaparova, L.

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    AU - Burkeev, M.Zh.

    AU - Kazhmuratova, A.T.

    AU - Zhumagaliyeva, T.S.

    AU - Ali, S.I.

    AU - Herk, van, A.M.

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    AB - Some aspects of the synthesis and characterization of polyethyl cyanoacrylate nanoparticles loaded with the antituberculosis drug capreomycin sulfate are considered in this work. Polyethyl cyanoacrylate nanoparticles containing capreomycin sulfate have been synthesized using anionic polymerization in emulsion. Optimum conditions of immobilization of the drug into the polymeric matrix have been found. It was determined that to increase the loading efficiency of the drug, it has to be added into the reaction medium after polymerization has started.

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