Synergistic targeting of alphavbeta3 integrin and galectin-1 with heteromultivalent paramagnetic liposomes for combined MR imaging and treatment of angiogenesis

E. Kluza, D.W.J. Schaft, van der, P.A.I. Hautvast, W.J.M. Mulder, K.H. Mayo, A.W. Griffioen, G.J. Strijkers, K. Nicolay

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Abstract

Effective and specific targeting of nanoparticles is of paramount importance in the fields of targeted therapeutics and diagnostics. In the current study, we investigated the targeting efficacy of nanoparticles that were functionalized with two angiogenesis-specific targeting ligands, an avß3 integrin-specific and a galectin-1-specific peptide. We show in vitro, using optical techniques and MRI, that the dual-targeting approach produces synergistic targeting effects, causing a dramatically elevated uptake of nanoparticles as compared to single ligand targeting.
Original languageEnglish
Pages (from-to)52-58
JournalNano Letters
Volume10
Issue number1
DOIs
Publication statusPublished - 2010

Fingerprint

Integrin alphaVbeta3
Galectin 1
angiogenesis
Liposomes
Nanoparticles
Imaging techniques
nanoparticles
Ligands
ligands
Integrins
Magnetic resonance imaging
Peptides
peptides

Cite this

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title = "Synergistic targeting of alphavbeta3 integrin and galectin-1 with heteromultivalent paramagnetic liposomes for combined MR imaging and treatment of angiogenesis",
abstract = "Effective and specific targeting of nanoparticles is of paramount importance in the fields of targeted therapeutics and diagnostics. In the current study, we investigated the targeting efficacy of nanoparticles that were functionalized with two angiogenesis-specific targeting ligands, an av{\ss}3 integrin-specific and a galectin-1-specific peptide. We show in vitro, using optical techniques and MRI, that the dual-targeting approach produces synergistic targeting effects, causing a dramatically elevated uptake of nanoparticles as compared to single ligand targeting.",
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Synergistic targeting of alphavbeta3 integrin and galectin-1 with heteromultivalent paramagnetic liposomes for combined MR imaging and treatment of angiogenesis. / Kluza, E.; Schaft, van der, D.W.J.; Hautvast, P.A.I.; Mulder, W.J.M.; Mayo, K.H.; Griffioen, A.W.; Strijkers, G.J.; Nicolay, K.

In: Nano Letters, Vol. 10, No. 1, 2010, p. 52-58.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Kluza, E.

AU - Schaft, van der, D.W.J.

AU - Hautvast, P.A.I.

AU - Mulder, W.J.M.

AU - Mayo, K.H.

AU - Griffioen, A.W.

AU - Strijkers, G.J.

AU - Nicolay, K.

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AB - Effective and specific targeting of nanoparticles is of paramount importance in the fields of targeted therapeutics and diagnostics. In the current study, we investigated the targeting efficacy of nanoparticles that were functionalized with two angiogenesis-specific targeting ligands, an avß3 integrin-specific and a galectin-1-specific peptide. We show in vitro, using optical techniques and MRI, that the dual-targeting approach produces synergistic targeting effects, causing a dramatically elevated uptake of nanoparticles as compared to single ligand targeting.

U2 - 10.1021/nl902659g

DO - 10.1021/nl902659g

M3 - Article

C2 - 19968235

VL - 10

SP - 52

EP - 58

JO - Nano Letters

JF - Nano Letters

SN - 1530-6984

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