Supramolecular polymer materials bring restorative heart valve therapy to patients

Tristan Mes, Aurelie Serrero, Hannah S. Bauer, Martijn A.J. Cox (Corresponding author), Anton W. Bosman, Patricia Y.W. Dankers (Corresponding author), E.W. Meijer

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)
176 Downloads (Pure)

Abstract

The functional restoration of natural tissues in a variety of cardiovascular applications is the main objective of Endogenous Tissue Restoration (ETR). The recent progress in the development of biocompatible, biodegradable, and tunable biomaterials with unprecedented properties allow the next steps from laboratory studies to clinical studies. The independent control over mechanical properties and biodegradability provided by the combination of covalent and non-covalent bonds makes supramolecular polymers uniquely qualified for ETR. This paper will provide further details on the mechanism of ETR and will provide a perspective on the preclinical and clinical application of supramolecular polymers for ETR. In addition to various reports on chronic studies in large animal models, three world-first clinical studies are reported, demonstrating the potential of supramolecular technology in bringing ETR to patients.

Original languageEnglish
Pages (from-to)175-187
Number of pages13
JournalMaterials Today
Volume52
DOIs
Publication statusPublished - 1 Jan 2022

Bibliographical note

Funding Information:
The authors would like to acknowledge prof. Carlijn Bouten and Dr. Anthal Smits from Eindhoven University of Technology for their scientific input and useful discussions.

Keywords

  • Clinical studies
  • Heart valves
  • Supramolecular polymers
  • Tissue engineering

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