Supramolecular polymer materials bring restorative heart valve therapy to patients

Tristan Mes; Aurelie Serrero; Hannah S. Bauer; Martijn A.J. Cox; Anton W. Bosman; Patricia Y.W. Dankers; E.W. Meijer

doi:10.1016/j.mattod.2021.12.003

Supramolecular polymer materials bring restorative heart valve therapy to patients

Tristan Mes, Aurelie Serrero, Hannah S. Bauer, Martijn A.J. Cox (Corresponding author), Anton W. Bosman, Patricia Y.W. Dankers (Corresponding author), E.W. Meijer

Research output: Contribution to journal › Review article › peer-review

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Abstract

The functional restoration of natural tissues in a variety of cardiovascular applications is the main objective of Endogenous Tissue Restoration (ETR). The recent progress in the development of biocompatible, biodegradable, and tunable biomaterials with unprecedented properties allow the next steps from laboratory studies to clinical studies. The independent control over mechanical properties and biodegradability provided by the combination of covalent and non-covalent bonds makes supramolecular polymers uniquely qualified for ETR. This paper will provide further details on the mechanism of ETR and will provide a perspective on the preclinical and clinical application of supramolecular polymers for ETR. In addition to various reports on chronic studies in large animal models, three world-first clinical studies are reported, demonstrating the potential of supramolecular technology in bringing ETR to patients.

Original language	English
Pages (from-to)	175-187
Number of pages	13
Journal	Materials Today
Volume	52
DOIs	https://doi.org/10.1016/j.mattod.2021.12.003
Publication status	Published - 1 Jan 2022

Bibliographical note

Funding Information:
The authors would like to acknowledge prof. Carlijn Bouten and Dr. Anthal Smits from Eindhoven University of Technology for their scientific input and useful discussions.

Funding

The authors would like to acknowledge prof. Carlijn Bouten and Dr. Anthal Smits from Eindhoven University of Technology for their scientific input and useful discussions.

Keywords

Clinical studies
Heart valves
Supramolecular polymers
Tissue engineering

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10.1016/j.mattod.2021.12.003

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title = "Supramolecular polymer materials bring restorative heart valve therapy to patients",

abstract = "The functional restoration of natural tissues in a variety of cardiovascular applications is the main objective of Endogenous Tissue Restoration (ETR). The recent progress in the development of biocompatible, biodegradable, and tunable biomaterials with unprecedented properties allow the next steps from laboratory studies to clinical studies. The independent control over mechanical properties and biodegradability provided by the combination of covalent and non-covalent bonds makes supramolecular polymers uniquely qualified for ETR. This paper will provide further details on the mechanism of ETR and will provide a perspective on the preclinical and clinical application of supramolecular polymers for ETR. In addition to various reports on chronic studies in large animal models, three world-first clinical studies are reported, demonstrating the potential of supramolecular technology in bringing ETR to patients.",

keywords = "Clinical studies, Heart valves, Supramolecular polymers, Tissue engineering",

author = "Tristan Mes and Aurelie Serrero and Bauer, {Hannah S.} and Cox, {Martijn A.J.} and Bosman, {Anton W.} and Dankers, {Patricia Y.W.} and E.W. Meijer",

note = "Funding Information: The authors would like to acknowledge prof. Carlijn Bouten and Dr. Anthal Smits from Eindhoven University of Technology for their scientific input and useful discussions. ",

year = "2022",

month = jan,

day = "1",

doi = "10.1016/j.mattod.2021.12.003",

language = "English",

volume = "52",

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journal = "Materials Today",

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T1 - Supramolecular polymer materials bring restorative heart valve therapy to patients

AU - Mes, Tristan

AU - Serrero, Aurelie

AU - Bauer, Hannah S.

AU - Cox, Martijn A.J.

AU - Bosman, Anton W.

AU - Dankers, Patricia Y.W.

AU - Meijer, E.W.

N1 - Funding Information: The authors would like to acknowledge prof. Carlijn Bouten and Dr. Anthal Smits from Eindhoven University of Technology for their scientific input and useful discussions.

PY - 2022/1/1

Y1 - 2022/1/1

N2 - The functional restoration of natural tissues in a variety of cardiovascular applications is the main objective of Endogenous Tissue Restoration (ETR). The recent progress in the development of biocompatible, biodegradable, and tunable biomaterials with unprecedented properties allow the next steps from laboratory studies to clinical studies. The independent control over mechanical properties and biodegradability provided by the combination of covalent and non-covalent bonds makes supramolecular polymers uniquely qualified for ETR. This paper will provide further details on the mechanism of ETR and will provide a perspective on the preclinical and clinical application of supramolecular polymers for ETR. In addition to various reports on chronic studies in large animal models, three world-first clinical studies are reported, demonstrating the potential of supramolecular technology in bringing ETR to patients.

AB - The functional restoration of natural tissues in a variety of cardiovascular applications is the main objective of Endogenous Tissue Restoration (ETR). The recent progress in the development of biocompatible, biodegradable, and tunable biomaterials with unprecedented properties allow the next steps from laboratory studies to clinical studies. The independent control over mechanical properties and biodegradability provided by the combination of covalent and non-covalent bonds makes supramolecular polymers uniquely qualified for ETR. This paper will provide further details on the mechanism of ETR and will provide a perspective on the preclinical and clinical application of supramolecular polymers for ETR. In addition to various reports on chronic studies in large animal models, three world-first clinical studies are reported, demonstrating the potential of supramolecular technology in bringing ETR to patients.

KW - Clinical studies

KW - Heart valves

KW - Supramolecular polymers

KW - Tissue engineering

UR - http://www.scopus.com/inward/record.url?scp=85121916011&partnerID=8YFLogxK

U2 - 10.1016/j.mattod.2021.12.003

DO - 10.1016/j.mattod.2021.12.003

M3 - Review article

AN - SCOPUS:85121916011

SN - 1369-7021

VL - 52

SP - 175

EP - 187

JO - Materials Today

JF - Materials Today

ER -

Supramolecular polymer materials bring restorative heart valve therapy to patients

Abstract

Bibliographical note

Funding

Keywords

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