Supramolecular control of enzyme activity through cucurbit[8]uril mediated dimerization

T.D. Dang, H. Nguyen, M. Merkx, L. Brunsveld

Research output: Contribution to journalArticleAcademicpeer-review

71 Citations (Scopus)
5 Downloads (Pure)

Abstract

At the double: Cucurbit[8]uril-mediated protein dimerization enables reversible control over strong enzyme activation of caspases. Simple addition of a short N-terminal FGG motif allows for a supramolecular-mediated 50-fold enhancement of caspase-9 catalytic activity.
Original languageEnglish
Pages (from-to)2915-2919
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number10
DOIs
Publication statusPublished - 2013

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