Supramolecular chemistry targeting proteins

S. van Dun, C. Ottmann, L.-G. Milroy, L. Brunsveld

Research output: Contribution to journalArticleAcademicpeer-review

127 Citations (Scopus)
155 Downloads (Pure)


The specific recognition of protein surface elements is a fundamental challenge in the life sciences. New developments in this field will form the basis of advanced therapeutic approaches and lead to applications such as sensors, affinity tags, immobilization techniques, and protein-based materials. Synthetic supramolecular molecules and materials are creating new opportunities for protein recognition that are orthogonal to classical small molecule and protein-based approaches. As outlined here, their unique molecular features enable the recognition of amino acids, peptides, and even whole protein surfaces, which can be applied to the modulation and assembly of proteins. We believe that structural insights into these processes are of great value for the further development of this field and have therefore focused this Perspective on contributions that provide such structural data.

Original languageEnglish
Pages (from-to)13960-13968
Number of pages9
JournalJournal of the American Chemical Society
Issue number40
Publication statusPublished - 11 Oct 2017


  • Journal Article


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