Supramolecular biomaterials based on ureidopyrimidinone and benzene-1,3,5-tricarboxamide moieties

Maarten H. Bakker, Patricia Y.W. Dankers

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

1 Citation (Scopus)

Abstract

Supramolecular polymer materials based on hydrogen-bonding motifs have been developed for their use in biomedical applications. In this chapter, the latest advances in supramolecular biomaterials research based on two different hydrogen-bonding units, i.e., the ureidopyrimidinone (UPy) and benzene-1,3,5-tricarboxamide (BTA) moiety, are presented. Based on the chemical structure and the method of formulation, three different types of biomaterials are identified, (i) solid scaffolds, (ii) hydrogels, and (iii) particles in solution. Approximately a decade ago, the first UPy-based materials were introduced in the field of regenerative medicine as solid scaffolds. Most of the subsequent research on UPy biomaterials has focused on scaffold and hydrogel applications for renal regenerative medicine, cardiovascular in situ tissue engineering, and cardiac drug delivery. On the other hand, the disk-like BTA motif and its extended discotic versions have mainly been used as versatile supramolecular nanofibers in solution, for, e.g., cellular drug delivery and medical imaging. In general, a considerable amount of focus is directed toward the supramolecular functionalization of pristine, nonbioactive structures, and a wide variety of molecules, bioactive guests, screening techniques, and potential applications have been explored and are discussed in this chapter. This will show the broad chemical properties and the applicability of hydrogen-bonded supramolecular motifs in the field of regenerative medicine.

Original languageEnglish
Title of host publicationSelf-Assembling Biomaterials
Subtitle of host publicationMolecular Design, Characterization and Application in Biology and Medicine
PublisherAgon Elsevier
Pages177-204
Number of pages28
ISBN (Electronic)9780081020159
ISBN (Print)9780081020128
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Benzene-1,3,5-tricarboxamide
  • Fibers
  • Hydrogels
  • Supramolecular biomaterials
  • Surfaces
  • Ureidopyrimidinone

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    Bakker, M. H., & Dankers, P. Y. W. (2018). Supramolecular biomaterials based on ureidopyrimidinone and benzene-1,3,5-tricarboxamide moieties. In Self-Assembling Biomaterials: Molecular Design, Characterization and Application in Biology and Medicine (pp. 177-204). Agon Elsevier. https://doi.org/10.1016/B978-0-08-102015-9.00009-5