Supramolecular biomaterials

Matthew J. Webber, Eric A. Appel, E. W. Meijer, Robert Langer

Research output: Contribution to journalArticleAcademicpeer-review

1142 Citations (Scopus)
1 Downloads (Pure)


Polymers, ceramics and metals have historically dominated the application of materials in medicine. Yet rationally designed materials that exploit specific, directional, tunable and reversible non-covalent interactions offer unprecedented advantages: they enable modular and generalizable platforms with tunable mechanical, chemical and biological properties. Indeed, the reversible nature of supramolecular interactions gives rise to biomaterials that can sense and respond to physiological cues, or that mimic the structural and functional aspects of biological signalling. In this Review, we discuss the properties of several supramolecular biomaterials, as well as their applications in drug delivery, tissue engineering, regenerative medicine and immunology. We envision that supramolecular biomaterials will contribute to the development of new therapies that combine highly functional materials with unmatched patient- and application-specific tailoring of both material and biological properties.

Original languageEnglish
Pages (from-to)13-26
Number of pages14
JournalNature Materials
Issue number1
Publication statusPublished - 18 Dec 2015


Dive into the research topics of 'Supramolecular biomaterials'. Together they form a unique fingerprint.

Cite this