Supramolecular Additive-Initiated Controlled Atom Transfer Radical Polymerization of Zwitterionic Polymers on Ureido-pyrimidinone-Based Biomaterial Surfaces

Bastiaan D. Ippel; Muhabbat I. Komil; Paul A.A. Bartels; Serge H.M. Söntjens; Roy J.E.A. Boonen; Maarten M.J. Smulders; Patricia Y.W. Dankers

doi:10.1021/acs.macromol.0c00160

Supramolecular Additive-Initiated Controlled Atom Transfer Radical Polymerization of Zwitterionic Polymers on Ureido-pyrimidinone-Based Biomaterial Surfaces

Bastiaan D. Ippel, Muhabbat I. Komil, Paul A.A. Bartels, Serge H.M. Söntjens, Roy J.E.A. Boonen, Maarten M.J. Smulders, Patricia Y.W. Dankers (Corresponding author)

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

Abstract

Surface-initiated controlled radical polymerization is a popular technique for the modification of biomaterials with, for example, antifouling polymers. Here, we report on the functionalization of a supramolecular biomaterial with zwitterionic poly(sulfobetaine methacrylate) via atom transfer radical polymerization from a macroinitiator additive, which is embedded in the hard phase of the ureido-pyrimidinone-based material. Poly(sulfobetaine methacrylate) was successfully polymerized from these surfaces, and the polymerized sulfobetaine content, with corresponding antifouling properties, depended on both the macroinitiator additive concentration and polymerization time. Furthermore, the polymerization from the macroinitiator additive was successfully translated to functional electrospun scaffolds, showing the potential for this functionalization strategy in supramolecular material systems. ©

Original language	English
Pages (from-to)	4454–4464
Number of pages	11
Journal	Macromolecules
Volume	53
Issue number	11
DOIs	https://doi.org/10.1021/acs.macromol.0c00160
Publication status	Published - 9 Jun 2020

Funding

The authors would like to acknowledge H. M. Janssen for useful discussions, M. G. H. Verhoeven for collaboration on the XPS measurements, and P. P. K. H. Fransen for the synthesis of the UPy–COOH synthon. The ICMS Animation Studio is acknowledged for the design of some of the cartoons. This work was funded by the Ministry of Education, Culture and Science (Gravity Program 024.001.03) and ZonMW as part of the LSH 2Treat program (Project no. 436001003).

Funders	Funder number
ZonMw : Dutch Organisation for Health Research and Development	436001003
Ministerie van Onderwijs, Cultuur en Wetenschap	024.001.03

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10.1021/acs.macromol.0c00160

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Ippel, B. D., Komil, M. I., Bartels, P. A. A., Söntjens, S. H. M., Boonen, R. J. E. A., Smulders, M. M. J., & Dankers, P. Y. W. (2020). Supramolecular Additive-Initiated Controlled Atom Transfer Radical Polymerization of Zwitterionic Polymers on Ureido-pyrimidinone-Based Biomaterial Surfaces. Macromolecules, 53(11), 4454–4464. https://doi.org/10.1021/acs.macromol.0c00160

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abstract = "Surface-initiated controlled radical polymerization is a popular technique for the modification of biomaterials with, for example, antifouling polymers. Here, we report on the functionalization of a supramolecular biomaterial with zwitterionic poly(sulfobetaine methacrylate) via atom transfer radical polymerization from a macroinitiator additive, which is embedded in the hard phase of the ureido-pyrimidinone-based material. Poly(sulfobetaine methacrylate) was successfully polymerized from these surfaces, and the polymerized sulfobetaine content, with corresponding antifouling properties, depended on both the macroinitiator additive concentration and polymerization time. Furthermore, the polymerization from the macroinitiator additive was successfully translated to functional electrospun scaffolds, showing the potential for this functionalization strategy in supramolecular material systems. {\textcopyright}",

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Supramolecular Additive-Initiated Controlled Atom Transfer Radical Polymerization of Zwitterionic Polymers on Ureido-pyrimidinone-Based Biomaterial Surfaces. / Ippel, Bastiaan D.; Komil, Muhabbat I.; Bartels, Paul A.A. et al.
In: Macromolecules, Vol. 53, No. 11, 09.06.2020, p. 4454–4464.

Research output: Contribution to journal › Article › Academic › peer-review

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Supramolecular Additive-Initiated Controlled Atom Transfer Radical Polymerization of Zwitterionic Polymers on Ureido-pyrimidinone-Based Biomaterial Surfaces

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