Super-resolution ultrasound imaging

Kirsten Christensen-Jeffries; Olivier Couture; Paul A. Dayton; Yonina C. Eldar; Kullervo Hynynen; Fabian Kiessling; Meaghan O'Reilly; Gianmarco F. Pinton; Georg Schmitz; Meng Xing Tang; Mickael Tanter; Ruud J.G. van Sloun

doi:10.1016/j.ultrasmedbio.2019.11.013

Super-resolution ultrasound imaging

Kirsten Christensen-Jeffries, Olivier Couture (Corresponding author), Paul A. Dayton, Yonina C. Eldar, Kullervo Hynynen, Fabian Kiessling, Meaghan O'Reilly, Gianmarco F. Pinton, Georg Schmitz, Meng Xing Tang, Mickael Tanter, Ruud J.G. van Sloun

Research output: Contribution to journal › Review article › peer-review

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Abstract

The majority of exchanges of oxygen and nutrients are performed around vessels smaller than 100 μm, allowing cells to thrive everywhere in the body. Pathologies such as cancer, diabetes and arteriosclerosis can profoundly alter the microvasculature. Unfortunately, medical imaging modalities only provide indirect observation at this scale. Inspired by optical microscopy, ultrasound localization microscopy has bypassed the classic compromise between penetration and resolution in ultrasonic imaging. By localization of individual injected microbubbles and tracking of their displacement with a subwavelength resolution, vascular and velocity maps can be produced at the scale of the micrometer. Super-resolution ultrasound has also been performed through signal fluctuations with the same type of contrast agents, or through switching on and off nano-sized phase-change contrast agents. These techniques are now being applied pre-clinically and clinically for imaging of the microvasculature of the brain, kidney, skin, tumors and lymph nodes.

Original language	English
Pages (from-to)	865-891
Number of pages	27
Journal	Ultrasound in Medicine and Biology
Volume	46
Issue number	4
DOIs	https://doi.org/10.1016/j.ultrasmedbio.2019.11.013
Publication status	Published - Apr 2020

Funding

This project has received funding from the European Research Council under European Union Horizon H2020 Programme/ERC Consolidator Grant Agreement No. 772786-ResolveStroke (PI: Olivier Couture). The works of Fabian Kiessling and Georg Schmitz were supported by German Research Foundation/Deutsche Forschungsgemeinschaft (DFG) Grants KI 1072/5-1, KI 1072/11-1, SCHM1171/3-1 and SCHM 1171/4-1. Kullervo Hynynen and Meaghan O'Reilly both received support through the Canada Research Chair program. Meng-Xing Tang acknowledges the funding from Engineering and Physical Sciences Research Council EP/N015487/1, Cancer Research UK MDA C53470/A22353 and Imperial College Confidence-in-Concepts.

Funders	Funder number
Imperial College London
European Union's Horizon 2020 - Research and Innovation Framework Programme	772786
Engineering and Physical Sciences Research Council	EP/N015487/1
Cancer Research UK Cambridge Institute	MDA C53470/A22353
H2020 European Research Council
Deutsche Forschungsgemeinschaft	SCHM 1171/4-1, KI 1072/5-1, SCHM1171/3-1, KI 1072/11-1

Keywords

Brain
Contrast agents
Localization
Microbubbles
Microscopy
Microvessels
Super-resolution
Tumor
Ultrasound

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ultrasmedbio.2019.11.013

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Cite this

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title = "Super-resolution ultrasound imaging",

abstract = "The majority of exchanges of oxygen and nutrients are performed around vessels smaller than 100 μm, allowing cells to thrive everywhere in the body. Pathologies such as cancer, diabetes and arteriosclerosis can profoundly alter the microvasculature. Unfortunately, medical imaging modalities only provide indirect observation at this scale. Inspired by optical microscopy, ultrasound localization microscopy has bypassed the classic compromise between penetration and resolution in ultrasonic imaging. By localization of individual injected microbubbles and tracking of their displacement with a subwavelength resolution, vascular and velocity maps can be produced at the scale of the micrometer. Super-resolution ultrasound has also been performed through signal fluctuations with the same type of contrast agents, or through switching on and off nano-sized phase-change contrast agents. These techniques are now being applied pre-clinically and clinically for imaging of the microvasculature of the brain, kidney, skin, tumors and lymph nodes.",

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AU - Hynynen, Kullervo

AU - Kiessling, Fabian

AU - O'Reilly, Meaghan

AU - Pinton, Gianmarco F.

AU - Schmitz, Georg

AU - Tang, Meng Xing

AU - Tanter, Mickael

AU - van Sloun, Ruud J.G.

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KW - Brain

KW - Contrast agents

KW - Localization

KW - Microbubbles

KW - Microscopy

KW - Microvessels

KW - Super-resolution

KW - Tumor

KW - Ultrasound

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ER -

Super-resolution ultrasound imaging

Abstract

Funding

Keywords

UN SDGs

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