Strong and reversible monovalent supramolecular protein immobilization

J.F. Young, H. Nguyen, L. Yang, J. Huskens, P. Jonkheijm, L. Brunsveld

Research output: Contribution to journalArticleAcademicpeer-review

73 Citations (Scopus)
3 Downloads (Pure)

Abstract

Proteins with an iron clasp: Site-selective incorporation of a ferrocene molecule into a protein allows for easy, strong, and reversible supramolecular protein immobilization through a selective monovalent interaction of the ferrocene with a cucurbit[7]uril immobilized on a gold surface. The proteins can be printed in a uniform monolayer that is resistant to washing conditions, but can be removed through competition with an excess of ferrocene ligand.
Original languageEnglish
Pages (from-to)180-183
JournalChemBioChem
Volume11
Issue number2
DOIs
Publication statusPublished - 2010

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